CLCA1 - chloride channel accessory 1 Gene

中文名称：氯离子通道附件 1

种属: Homo sapiens

同用名: CACC; GOB5; CACC1; CLCRG1; CaCC-1; hCLCA1; hCaCC-1

基因 ID: 1179 | 基因类型: protein coding

关于 CLCA1

Cytogenetic location: 1p22.3 Genomic coordinates (GRCh38): 1:86,468,927-86,500,259 (from NCBI)

This gene has 2 transcripts (splice variants), 237 orthologues and 2 paralogues. Biased expression in small intestine (RPKM 634.9), duodenum (RPKM 392.5) and 2 other tissues.

功能概要

该基因编码钙敏感性氯化物电导蛋白家族的成员。迄今为止，该基因家族的所有成员都映射到染色体 1p31-p22 上的同一区域，并且在大小、序列和预测结构上具有高度同源性，但在组织分布上存在显着差异。编码的蛋白质被表达为前体蛋白，被加工成两个细胞表面相关的亚基，尽管前体被切割的位点尚未精确确定。编码的蛋白质可能参与介导肠道中钙激活的氯化物电导。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. [provided by RefSeq, Jul 2008]

CLCA1 基因产物(1)

mRNA	Protein	Name
NM_001285.4	NP_001276.3	calcium-activated chloride channel regulator 1 precursor

CLCA1 蛋白结构

CLCA

VWA_2

0
200
400
600
800
914 a.a.

蛋白主名

其他名称

calcium-activated chloride channel regulator 1

CLCA family member 1, chloride channel regulator

关联疾病

疾病名称

别名

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Pontocerebellar Hypoplasia, Type 9

Pontocerebellar Hypoplasia Type 9	PCH9
Pontocerebellar Hypoplasia 9	Hypoplasia, Pontocerebellar, Type 9

Ileus

Ileus Of Intestine

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

T2-High Asthma

Type 2 High Endotype

Pulmonary Disease, Chronic Obstructive

Chronic Obstructive Pulmonary Disease	COPD
Pulmonary Disease, Chronic Obstructive, Severe Early-Onset	Chronic Obstructive Lung Disease
Chronic Obstructive Airway Disease	Pulmonary Disease, Chronic Obstructive, Susceptibility To
Cold	Severe Early-Onset Chronic Obstructive Pulmonary Disease
Pulmonary Disease Chronic Obstructive	Pulmonary Disease, Obstructive, Chronic, Susceptibility To
Chronic Obstructive Pulmonary Disease Of Horses	Common Cold
Upper Respiratory Infections	Copd - [Chronic Obstructive Pulmonary Disease]
Coad - [Chronic Obstructive Airways Disease]	Cold - [Chronic Obstructive Lung Disease]
Chronic Airway Disease Nos	Chronic Airways Limitation, Unspecified
Chronic Obstructed Airway, Unspecified	Chronic Obstructive Airway Disease, Unspecified
Chronic Obstructive Airway, Unspecified	Obstructive Lung Disease Nos
Chronic Obstructive Lung Disease Nos	Chronic Obstructive Lung Nos
Obstructive Pulmonary Disease Nos	Exacerbation Copd Nos
Acute Exacerbation Copd

Adult-Onset Severe Asthma

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02748	CLCA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	CLCA1	VGNC	VGNC:27392
Canis familiaris	CLCA1	VGNC	VGNC:39296
Rattus norvegicus	CLCA1	RGD	RGD:1306258
Felis catus	CLCA1	VGNC	VGNC:60918
Mus musculus	CLCA1	MGD	MGI:1346342

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CLCA1 - chloride channel accessory 1 Gene

关于 CLCA1

功能概要

CLCA1 基因产物(1)

CLCA1 蛋白结构

关联疾病

直系同源

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CLCA1 - chloride channel accessory 1 Gene

关于 CLCA1

功能概要

CLCA1 基因产物(1)

CLCA1 蛋白结构

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

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