Bcl6 - B cell leukemia/lymphoma 6 Gene

种属: Mus musculus

同用名: Bcl5

基因 ID: 12053 | 基因类型: protein coding

关于 Bcl6

功能概要

Enables DNA binding activity and DNA-binding transcription repressor activity, RNA polymerase II-specific. Acts upstream of or within several processes, including hemopoiesis; negative regulation of signal transduction; and regulation of lymphocyte activation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and liver and biliary system. Human ortholog(s) of this gene implicated in B-cell lymphoma and diffuse large B-cell lymphoma. Orthologous to human BCL6 (BCL6 transcription repressor). [provided by Alliance of Genome Resources, Apr 2022]

Bcl6 基因产物(2)

mRNA	Protein	Name
NM_001348026.1	NP_001334955.1	B-cell lymphoma 6 protein homolog
NM_009744.4	NP_033874.1	B-cell lymphoma 6 protein homolog

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	12097386	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	9110977	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	12097386	MGI
enables chromatin DNA binding	IDA IDA: 通过直接分析推断	17125145	MGI
enables chromatin binding	IDA IDA: 通过直接分析推断	12817026	MGI
enables intronic transcription regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	24863065	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	9632807	MGI
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	15659391	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within B cell differentiation	IGI IGI: 通过遗传相互作用推断	14647274	MGI
acts upstream of B cell proliferation	IMP IMP: 通过突变表型推断	9171827	MGI
acts upstream of or within Rho protein signal transduction	IGI IGI: 通过遗传相互作用推断	15860730	MGI
acts upstream of Rho protein signal transduction	IMP IMP: 通过突变表型推断	15860730	MGI
acts upstream of T-helper 2 cell differentiation	IGI IGI: 通过遗传相互作用推断	12594267	MGI
acts upstream of or within actin cytoskeleton organization	IMP IMP: 通过突变表型推断	15860730	MGI
acts upstream of or within cell morphogenesis	IGI IGI: 通过遗传相互作用推断	15860730	MGI
acts upstream of or within cell morphogenesis	IMP IMP: 通过突变表型推断	15860730	MGI
acts upstream of cell motility	IMP IMP: 通过突变表型推断	15860730	MGI
acts upstream of cell population proliferation	IMP IMP: 通过突变表型推断	15507530	MGI
acts upstream of cell-matrix adhesion	IMP IMP: 通过突变表型推断	15860730	MGI
acts upstream of or within erythrocyte development	IMP IMP: 通过突变表型推断	15661395	MGI
acts upstream of or within germinal center formation	IMP IMP: 通过突变表型推断	9110977	MGI
acts upstream of or within heterochromatin formation	IGI IGI: 通过遗传相互作用推断	23160044	MGI
acts upstream of isotype switching to IgE isotypes	IGI IGI: 通过遗传相互作用推断	10490661	MGI
acts upstream of isotype switching to IgE isotypes	IMP IMP: 通过突变表型推断	10490661	MGI
acts upstream of mast cell cytokine production	IMP IMP: 通过突变表型推断	15950739	MGI
acts upstream of mononuclear cell proliferation	IMP IMP: 通过突变表型推断	15507530	MGI
acts upstream of or within negative regulation of Notch signaling pathway	IGI IGI: 通过遗传相互作用推断	23160044	MGI
acts upstream of or within negative regulation of Rho protein signal transduction	IMP IMP: 通过突变表型推断	15860730	MGI
acts upstream of or within negative regulation of T-helper 2 cell differentiation	IGI IGI: 通过遗传相互作用推断	12594267	MGI
acts upstream of or within negative regulation of apoptotic process	IDA IDA: 通过直接分析推断	9927203	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	11092811	MGI
acts upstream of or within negative regulation of cell-matrix adhesion	IMP IMP: 通过突变表型推断	15860730	MGI
acts upstream of or within negative regulation of cellular senescence	IMP IMP: 通过突变表型推断	23209284	MGI
acts upstream of or within negative regulation of isotype switching to IgE isotypes	IGI IGI: 通过遗传相互作用推断	10490661	MGI
acts upstream of or within negative regulation of isotype switching to IgE isotypes	IMP IMP: 通过突变表型推断	10490661	MGI
acts upstream of or within negative regulation of mast cell cytokine production	IMP IMP: 通过突变表型推断	15950739	MGI
acts upstream of or within negative regulation of mononuclear cell proliferation	IMP IMP: 通过突变表型推断	15507530	MGI
acts upstream of or within negative regulation of plasma cell differentiation	IMP IMP: 通过突变表型推断	15240705	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	9632807	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	12097386	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	9110977	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	15611242	MGI
acts upstream of or within negative regulation of type 2 immune response	IGI IGI: 通过遗传相互作用推断	10438949	MGI
acts upstream of plasma cell differentiation	IMP IMP: 通过突变表型推断	15240705	MGI
acts upstream of or within positive regulation of B cell proliferation	IMP IMP: 通过突变表型推断	9171827	MGI
acts upstream of or within positive regulation of cell motility	IMP IMP: 通过突变表型推断	15860730	MGI
acts upstream of or within positive regulation of neuron differentiation	IDA IDA: 通过直接分析推断	23160044	MGI
acts upstream of or within protein localization	IMP IMP: 通过突变表型推断	15860730	MGI
acts upstream of pyramidal neuron differentiation	IDA IDA: 通过直接分析推断	23160044	MGI
acts upstream of or within regulation of GTPase activity	IMP IMP: 通过突变表型推断	15860730	MGI
acts upstream of or within regulation of T cell proliferation	IMP IMP: 通过突变表型推断	15240675	MGI
acts upstream of or within regulation of inflammatory response	IMP IMP: 通过突变表型推断	9110977	MGI
acts upstream of or within regulation of memory T cell differentiation	IMP IMP: 通过突变表型推断	15240675	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	24863065	MGI
acts upstream of or within spermatogenesis	IMP IMP: 通过突变表型推断	11092811	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	23160044	MGI
acts upstream of or within type 2 immune response	IMP IMP: 通过突变表型推断	9171827	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	9632807	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

B-cell lymphoma 6 protein homolog

B-cell leukemia/lymphoma 5

目录号	产品名	作用方式	纯度	Phase
HY-158105	ARV-393	Degrader	99.43%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-N2334	Glycochenodeoxycholic acid	Activator	99.84%	否
HY-N2334A	Glycochenodeoxycholic acid sodium salt	Activator	98.51%	否
HY-156595	BCL6 ligand-1		99.66%	否
HY-172736	BMS-986458	Degrader	99.65%	否
HY-161138	WK369	Inhibitor	99.89%	否
HY-169245	CDK-TCIP2	Inhibitor	98.94%	否
HY-153521	CCT374705	Inhibitor	99.30%	否
HY-173552	TCIP3	Inhibitor	99.30%	否
HY-161989	DZ-837		96.04%	否
HY-173364	EB-TCIP	Inducer	98.74%	否
HY-143653	BCL6-IN-6		98.10%	否
HY-P10566	BCOR(498-514), biotinylated	Inhibitor	/	否
HY-122829	BCL6 PROTAC 1	Degrader	/	否
HY-173641	MNN-02-155		/	否
HY-178804	BCL6 ligand-5	Ligand	/	否
HY-178777	BCL6-760	Degrader	/	否
HY-176382	BCL6 ligand-4		/	否
HY-164098	JWZ-7-7-Neg1	Inhibitor	/	否
HY-P10543	SMRT peptide	Inhibitor	/	否
HY-169218	WK692	Inhibitor	/	否
HY-178803	PROTAC BCL6 Degrader-2	Degrader	/	否
HY-168907	OICR11029		/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Bcl6	NCBI	NCBI:604

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