2. Gene
  3. Gab2 - growth factor receptor bound protein 2-associated protein 2 Gene

Gab2 - growth factor receptor bound protein 2-associated protein 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: p97; D130058I17Rik

基因 ID: 14389 | 基因类型: protein coding

关于 Gab2

功能概要

Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in several processes, including osteoclast differentiation; phosphatidylinositol-mediated signaling; and positive regulation of mast cell degranulation. Acts upstream of or within cell migration and integrin-mediated signaling pathway. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of protein-containing complex. Is expressed in basal forebrain; cerebral cortex; diencephalon; and intestine smooth muscle circular layer. Orthologous to several human genes including GAB2 (GRB2 associated binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Gab2 基因产物(2)

mRNA Protein Name
NM_001162477.1 NP_001155949.1 GRB2-associated-binding protein 2 isoform 2
NM_010248.2 NP_034378.2 GRB2-associated-binding protein 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: 通过直接分析推断
16456001 MGI
enables phosphatidylinositol-3,4-bisphosphate binding IDA
IDA: 通过直接分析推断
16456001 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15750601 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cell migration IDA
IDA: 通过直接分析推断
11895767 MGI
acts upstream of or within integrin-mediated signaling pathway IDA
IDA: 通过直接分析推断
11895767 MGI
involved in osteoclast differentiation IMP
IMP: 通过突变表型推断
15750601 MGI
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
11449275 MGI
involved in positive regulation of epithelial cell migration IMP
IMP: 通过突变表型推断
23401857 MGI
involved in positive regulation of mast cell degranulation IMP
IMP: 通过突变表型推断
11449275 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane raft IDA
IDA: 通过直接分析推断
23478294 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

GRB2-associated-binding protein 2

GRB2-associated binder 2

Grb2 associated binder 2

PH domain-containing adaptor molecule p97

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05198 GAB2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22177 Gab2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28699 Gab2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gab2 NCBI NCBI:9846
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