Hras - Harvey rat sarcoma virus oncogene Gene

中文名称：哈维大鼠肉瘤病毒致癌基因

种属: Mus musculus

同用名: ras; H-ras; Hras1; Kras2; Ha-ras; Hras-1; c-H-ras; c-rasHa; c-Ha-ras; Harvey-ras

关于 Hras

功能概要

该基因编码的蛋白可启动 GTP 绑定活动。参与 Ras 蛋白信号转导。作用于多个过程的上游或内部，包括对原生动物的防御反应；细胞内信号转导；和干扰素-γ 产生的正向调节。预测位于高尔基体；胞质溶胶；和核质。预计在谷氨酸能突触和质膜中活跃。以多种结构表达，包括中枢神经系统；早期胚胎；后肾;感觉器官；和牙齿。用于研究Costello综合征；高级别神经胶质瘤；和恶性星形细胞瘤。该基因的人类直系同源物与多种疾病有关，包括 Costello 综合征；自闭症；癌（多发性）；表皮痣;和巨大的先天性黑色素细胞痣。与人类 HRAS（HRas 原癌基因，GTPase）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables GTP binding activity. Involved in Ras protein signal transduction. Acts upstream of or within several processes, including defense response to protozoan; intracellular signal transduction; and positive regulation of interferon-gamma production. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in glutamatergic synapse and plasma membrane. Is expressed in several structures, including central nervous system; early embryo; metanephros; sensory organ; and tooth. Used to study Costello syndrome; high grade glioma; and malignant astrocytoma. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]