2. Gene
  3. DNAJB8 - DnaJ heat shock protein family (Hsp40) member B8 Gene

DNAJB8 - DnaJ heat shock protein family (Hsp40) member B8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：DnaJ 热休克蛋白家族 (Hsp40) 成员 B8

种属: Homo sapiens

同用名: DJ6; CT156

基因 ID: 165721 | 基因类型: protein coding

关于 DNAJB8

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:128,462,437-128,466,890 (from NCBI)

This gene has 2 transcripts (splice variants), 412 orthologues and 11 paralogues. Restricted expression toward testis (RPKM 16.6).

功能概要

该基因编码的蛋白质属于调节伴侣活性的 DNAJ/HSP40 蛋白质家族。该家族成员抑制聚谷氨酰胺蛋白的聚集和毒性，而 C 末端尾巴对于该活性至关重要。它被认为是癌症-睾丸抗原和参与肾细胞癌的癌症干细胞样细胞抗原。[RefSeq 提供，2012 年 6 月]

The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is essential for this activity. It has been implicated as a cancer-testis antigen and as a Cancer stem-like cell antigen involved in renal cell carcinoma. [provided by RefSeq, Jun 2012]

DNAJB8 基因产物(1)

mRNA Protein Name
NM_153330.6 NP_699161.1 dnaJ homolog subfamily B member 8
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein folding chaperone IDA
IDA: 通过直接分析推断
23612975 GOA
enables protein-folding chaperone binding IPI
IPI: 通过物理相互作用推断
21231916 GOA
enables unfolded protein binding IDA
IDA: 通过直接分析推断
21231916 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within chaperone-mediated protein folding IDA
IDA: 通过直接分析推断
23612975 GOA
involved in negative regulation of inclusion body assembly IDA
IDA: 通过直接分析推断
21231916 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
21231916 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21231916 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DNAJB8 蛋白结构

DnaJ

DnaJ: DnaJ domain (3 - 66)

  • 0
  • 100
  • 200
  • 232 a.a.
蛋白主名 其他名称

dnaJ homolog subfamily B member 8

DnaJ (Hsp40) homolog, subfamily B, member 8

关联疾病

疾病名称 别名
Fatal Infantile Hypertonic Myofibrillar Myopathy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03870 DNAJB8 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus DNAJB8 RGD RGD:1561981
Canis familiaris DNAJB8 VGNC VGNC:54595
Felis catus DNAJB8 VGNC VGNC:78442
Mus musculus DNAJB8 MGD MGI:1922801
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