2. Gene
  3. Slc11a2 - solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Gene

Slc11a2 - solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: mk; van; DCT1; DMT1; Nramp2

基因 ID: 18174 | 基因类型: protein coding

关于 Slc11a2

功能概要

Enables cobalt ion transmembrane transporter activity; ferrous iron transmembrane transporter activity; and proton transmembrane transporter activity. Acts upstream of or within several processes, including cation transport; erythrocyte development; and multicellular organismal iron ion homeostasis. Located in several cellular components, including brush border membrane; endosome; and extracellular vesicle. Is integral component of plasma membrane. Is expressed in embryo; intestine; small intestine; and yolk sac. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; anemia; and hypochromic anemia. Orthologous to human SLC11A2 (solute carrier family 11 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc11a2 基因产物(3)

mRNA Protein Name
NM_001146161.1 NP_001139633.1 natural resistance-associated macrophage protein 2 isoform 1
NM_001356952.1 NP_001343881.1 natural resistance-associated macrophage protein 2 isoform 3
NM_008732.2 NP_032758.2 natural resistance-associated macrophage protein 2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cobalt ion transmembrane transporter activity IDA
IDA: 通过直接分析推断
12522007 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cobalt ion transport IDA
IDA: 通过直接分析推断
12724326 MGI
acts upstream of or within dendrite morphogenesis IMP
IMP: 通过突变表型推断
19211831 MGI
acts upstream of or within erythrocyte development IMP
IMP: 通过突变表型推断
15849611 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: 通过突变表型推断
807277 MGI
acts upstream of or within heme biosynthetic process IMP
IMP: 通过突变表型推断
11739192 MGI
acts upstream of or within iron import into cell IMP
IMP: 通过突变表型推断
11739192 MGI
acts upstream of or within iron ion transport IMP
IMP: 通过突变表型推断
807277 MGI
acts upstream of or within learning or memory IMP
IMP: 通过突变表型推断
19211831 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IMP
IMP: 通过突变表型推断
5070129 MGI
acts upstream of or within porphyrin-containing compound biosynthetic process IMP
IMP: 通过突变表型推断
658175 MGI
acts upstream of or within porphyrin-containing compound metabolic process IMP
IMP: 通过突变表型推断
4404581 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in brush border membrane IGI
IGI: 通过遗传相互作用推断
19252488 MGI
located in endosome IDA
IDA: 通过直接分析推断
16227996 MGI
located in extracellular vesicle IDA
IDA: 通过直接分析推断
27462458 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
16227996 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

natural resistance-associated macrophage protein 2

DMT-1

NRAMP 2

divalent cation transporter 1

divalent metal transporter 1

microcytic anemia, viable anaemia

solute carrier family 11 member 2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12995 SLC11A2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20644 Slc11a2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27154 Slc11a2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Slc11a2 NCBI NCBI:4891
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