2. Gene
  3. Pde4a - phosphodiesterase 4A, cAMP specific Gene

Pde4a - phosphodiesterase 4A, cAMP specific Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：磷酸二酯酶 4A，cAMP 特异性

种属: Mus musculus

同用名: Dpde2; D9Ertd60e

基因 ID: 18577 | 基因类型: protein coding

关于 Pde4a

Chromosome 9: 21,077,010-21,124,544 forward strand.GRCm39:CM001002.3

This gene has 5 transcripts (splice variants), 261 orthologues and 20 paralogues. Broad expression in testis adult (RPKM 2.4), frontal lobe adult (RPKM 16.) and 22 other tissues.

功能概要

该基因编码的蛋白可启动 3',5'-环状 AMP 磷酸二酯酶活性。作用于对异生素刺激的细胞反应的上游或内部；调节信号转导；和嗅觉的感官知觉。位于胞质溶胶和膜中。以多种结构表达，包括消化系统；心;外皮系统；神经系统;和感觉器官。与人 PDE4A（磷酸二酯酶 4A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables 3',5'-cyclic-AMP phosphodiesterase activity. Acts upstream of or within cellular response to xenobiotic stimulus; regulation of signal transduction; and sensory perception of smell. Located in cytosol and membrane. Is expressed in several structures, including alimentary system; heart; integumental system; nervous system; and sensory organ. Orthologous to human PDE4A (phosphodiesterase 4A). [provided by Alliance of Genome Resources, Apr 2022]

Pde4a 基因产物(11)

mRNA Protein Name
NM_001409297.1 NP_001396226.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 10
NM_001409295.1 NP_001396224.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 9
NM_001409293.1 NP_001396222.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 8
NM_019798.6 NP_062772.3 cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 1
NM_001409294.1 NP_001396223.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 8
NM_001409292.1 NP_001396221.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 7
NM_001409296.1 NP_001396225.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 10
NM_001310750.2 NP_001297679.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 6
NM_001409289.1 NP_001396218.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
NM_001409291.1 NP_001396220.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4
NM_183408.4 NP_899668.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 5

Pde4a 蛋白结构

PDE4_UCR

PDE4_UCR: pfam18100 (172 - 287)

PDEase_I

PDEase_I: pfam00233 (417 - 657)

  • 0
  • 200
  • 400
  • 600
  • 844 a.a.
蛋白主名 其他名称

cAMP-specific 3',5'-cyclic phosphodiesterase 4A

cAMP-specific phosphodiesterase PDE4A

cyclic AMP specific phosphodiesterase PDE4A5A

dunce

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B1639 Enoximone Inhibitor 98.07% 否
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-16900 Rolipram Inhibitor 99.58% Phase 2
HY-106003 GSK356278 Inhibitor 99.82% Phase 1
Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-16900A (R)-(-)-Rolipram Inhibitor 99.89% 否
HY-119190 PF-06445974 Inhibitor 98.23% 否
HY-103050 ML-030 Inhibitor 99.50% 否
HY-131707 LEO 39652 Inhibitor 99.51% 否
HY-131340 LASSBio-1632 Inhibitor / 否
HY-122167 L-869298 Inhibitor / 否
HY-RS10220 PDE4A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10221 Pde4a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10222 Pde4a Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pde4a NCBI NCBI:5141
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z