2. Gene
  3. Prkar1a - protein kinase, cAMP dependent regulatory, type I, alpha Gene

Prkar1a - protein kinase, cAMP dependent regulatory, type I, alpha Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Tse1; Tse-1; RIalpha; 1300018C22Rik

基因 ID: 19084 | 基因类型: protein coding

关于 Prkar1a

功能概要

The encoded protein is a regulatory subunit of the cAMP-dependent protein kinase (PKA) complex, which is responsible for transducing most of the cAMP signals in eukaryotic cells. The inactive PKA complex contains two regulatory and two catalytic subunits. Binding of cAMP dissociates the complex, allowing monomeric catalytic subunits to phosphorylate cytosolic proteins or induce gene expression in the nucleus. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2015]

Prkar1a 基因产物(8)

mRNA Protein Name
NM_001313973.2 NP_001300902.1 cAMP-dependent protein kinase type I-alpha regulatory subunit
NM_001313974.2 NP_001300903.1 cAMP-dependent protein kinase type I-alpha regulatory subunit
NM_001313975.2 NP_001300904.1 cAMP-dependent protein kinase type I-alpha regulatory subunit
NM_001313976.2 NP_001300905.1 cAMP-dependent protein kinase type I-alpha regulatory subunit
NM_001362677.1 NP_001349606.1 cAMP-dependent protein kinase type I-alpha regulatory subunit
NM_001373912.1 NP_001360841.1 cAMP-dependent protein kinase type I-alpha regulatory subunit
NM_001373913.1 NP_001360842.1 cAMP-dependent protein kinase type I-alpha regulatory subunit
NM_021880.4 NP_068680.1 cAMP-dependent protein kinase type I-alpha regulatory subunit
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cAMP-dependent protein kinase inhibitor activity IMP
IMP: 通过突变表型推断
27803029 MGI
enables cAMP-dependent protein kinase regulator activity IDA
IDA: 通过直接分析推断
7775586 MGI
enables cAMP-dependent protein kinase regulator activity IGI
IGI: 通过遗传相互作用推断
12004056 MGI
enables cAMP-dependent protein kinase regulator activity IMP
IMP: 通过突变表型推断
12004056 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9852104 MGI
enables protein kinase A catalytic subunit binding IPI
IPI: 通过物理相互作用推断
30026308 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
9075801 MGI
acts upstream of or within cardiac muscle cell proliferation IMP
IMP: 通过突变表型推断
18316483 MGI
involved in cellular response to glucagon stimulus IMP
IMP: 通过突变表型推断
32735622 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
18316483 MGI
acts upstream of or within mesoderm formation IMP
IMP: 通过突变表型推断
12004056 MGI
acts upstream of or within negative regulation of protein kinase activity IMP
IMP: 通过突变表型推断
18316483 MGI
involved in positive regulation of insulin secretion IMP
IMP: 通过突变表型推断
9075801 MGI
acts upstream of or within sarcomere organization IMP
IMP: 通过突变表型推断
18316483 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of cAMP-dependent protein kinase complex IDA
IDA: 通过直接分析推断
21502359 MGI
located in centrosome IDA
IDA: 通过直接分析推断
30026308 MGI
is active in cytoplasm IDA
IDA: 通过直接分析推断
21502359 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
30026308 MGI
is active in cytosol IDA
IDA: 通过直接分析推断
33185461 MGI
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
24413018 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
24413018 MGI
located in multivesicular body IDA
IDA: 通过直接分析推断
21502359 MGI
located in neuromuscular junction IDA
IDA: 通过直接分析推断
8794865 MGI
located in sperm head-tail coupling apparatus IDA
IDA: 通过直接分析推断
30026308 MGI
is active in synapse EXP
EXP: 通过实验结果推断
24413018 MGI
is active in synapse IDA
IDA: 通过直接分析推断
24413018 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cAMP-dependent protein kinase type I-alpha regulatory subunit

protein kinase, cAMP dependent regulatory, type 1, alpha

Prkar1a 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Prkar1a Q9DBC7 Bcl2l11 Mus musculus O54918-1
Anti Tag CoIP
21151042
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 Prkar1a 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75982 PRKAR1A Protein, Mouse (sf9, His) Q9DBC7 (M1-V381) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11112 PRKAR1A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17722 Prkar1a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24187 Prkar1a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Prkar1a NCBI NCBI:5573
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