1. Gene
  2. CELA1 - chymotrypsin like elastase 1 Gene

CELA1 - chymotrypsin like elastase 1 Gene

中文名称:胰凝乳蛋白酶样弹性蛋白酶 1

种属: Homo sapiens

同用名: ELA1

基因 ID: 1990 | 基因类型: protein coding

关于 CELA1

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:51,328,442-51,346,679 (from NCBI)

This gene has 1 transcript (splice variant), 325 orthologues and 6 paralogues. Low expression observed in reference dataset.

功能概要

弹性蛋白酶形成丝氨酸蛋白酶的一个亚家族,除了弹性蛋白之外,它还能水解许多蛋白质。人类有六个弹性蛋白酶基因,它们编码结构相似的蛋白质弹性蛋白酶 1、2、2A、2B、3A 和 3B。与其他弹性蛋白酶不同,胰腺弹性蛋白酶 1 不在胰腺中表达。迄今为止,仅在皮肤角质形成细胞中检测到弹性蛋白酶 1 的表达。描述胰腺或粪便中人弹性蛋白酶 1 活性的临床文献实际上是指胰凝乳蛋白酶样弹性蛋白酶家族成员 3B。[RefSeq 提供,2009 年 5 月]

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six Elastase genes which encode the structurally similar proteins Elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, pancreatic Elastase 1 is not expressed in the pancreas. To date, Elastase 1 expression has only been detected in skin keratinocytes. Clinical literature that describes human Elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like Elastase family, member 3B. [provided by RefSeq, May 2009]

CELA1 基因产物(1)

mRNA Protein Name
NM_001971.6 NP_001962.3 chymotrypsin-like elastase family member 1

CELA1 蛋白结构

Trypsin

Trypsin: Trypsin (19 - 251)

  • 0
  • 100
  • 200
  • 258 a.a.
蛋白主名 其他名称

chymotrypsin-like elastase family member 1

chymotrypsin like elastase family member 1

关联疾病

疾病名称 别名
Pancreatic Steatorrhea

Pancreatic Steatorrhoea

Decreased Tolerance Of Pancreas

Pancreatic Disturbance Of Fat Absorption

Pancreatic Acinar Cell Adenocarcinoma

Pancreatic Acinar Cell Carcinoma

Acinar Cell Adenocarcinoma Of The Pancreas

Autoimmune Pancreatitis

Lymphoplasmocytic Sclerosing Pancreatitis

Aip

Exocrine Pancreatic Insufficiency
Biliary Dyskinesia

Sphincter Of Oddi Dysfunction

Acute Necrotizing Pancreatitis

Pancreatitis, Acute Necrotizing

Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus CELA1 VGNC VGNC:27166
Macaca mulatta CELA1 VGNC VGNC:71152
Felis catus CELA1 VGNC VGNC:60743
Canis familiaris CELA1 VGNC VGNC:39092
Mus musculus CELA1 MGD MGI:95314
Rattus norvegicus CELA1 RGD RGD:2547