DAND5 - DAN domain BMP antagonist family member 5 Gene

中文名称：DAN 结构域 BMP 拮抗因子家族成员 5

种属: Homo sapiens

同用名: SP1; CER2; COCO; CRL2; CERL2; DANTE; GREM3; CKTSF1B3

基因 ID: 199699 | 基因类型: protein coding

关于 DAND5

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,969,576-12,974,760 (from NCBI)

This gene has 2 transcripts (splice variants), 132 orthologues and 1 paralogue. Biased expression in heart (RPKM 2.6), brain (RPKM 0.4) and 1 other tissue.

功能概要

该基因编码 BMP (骨形态发生蛋白) 拮抗剂家族的成员。与 BMP 一样，BMP 拮抗剂含有胱氨酸结，通常形成同二聚体和异二聚体。该基因所属的 BMP 拮抗剂的 CAN (cerberus 和 dan) 亚家族的特征在于具有八元环的 C 末端胱氨酸结。由该基因编码的分泌蛋白的拮抗作用可能是由于它与 BMP 蛋白直接结合。作为 BMP 的拮抗剂，该基因可能在调节器官发生、身体形态和组织分化中发挥作用。在小鼠中，这种蛋白质已被证明可以结合 Nodal 并抑制影响左/右身体不对称的 Nodal 信号通路。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq, Jul 2008]

DAND5 基因产物(1)

mRNA	Protein	Name
NM_152654.3	NP_689867.1	DAN domain family member 5 precursor

DAND5 蛋白结构

DAN

0
100
189 a.a.

蛋白主名

其他名称

DAN domain family member 5

DAN domain family member 5, BMP antagonist

关联疾病

疾病名称

别名

Situs Inversus

Situs Inversus Viscerum	Laterality Sequence
Complete Transposition	Siv

Visceral Heterotaxy

Situs Ambiguus	Heterotaxia
Heterotaxy Syndrome	Heterotaxy
Lateralization Defect	Situs Ambiguous
Left Isomerism	Htx
Ivemark Syndrome	Right Isomerism
Situs Ambiguus Viscerum	Incomplete Situs Inversus
Partial Situs Inversus	Heterotaxy, Visceral
Asplenia Syndrome	Bilateral Left-Sidedness
Polysplenia Syndrome	Moller Syndrome

Sclerosteosis 1

SOST1	Sost
Cortical Hyperostosis With Syndactyly	Sclerosteosis
Sclerosteosis, Type 1

Marshall-Smith Syndrome

MRSHSS	Accelerated Skeletal Maturation-Facial Dysmorphism-Failure To Thrive Syndrome
Mss

Right Atrial Isomerism

Ivemark Syndrome	Asplenia With Cardiovascular Anomalies
RAI	Asplenia Syndrome
Asplenia	Right Isomerism
Splenic Agenesis Syndrome	Bilateral Right-Sidedness Sequence
Right Sided Atrial Isomerism	Isomerism Of Right Atrial Appendage
Heterotaxy, Visceroatrial, Autosomal Recessive	Polyasplenia
Vah, Autosomal Recessive	Atrial Isomerism, Right
Congenital Absence Of Spleen	Bilateral Right-Sidedness

Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 2	PKD2
Polycystic Kidney Disease, Adult, Type Ii	Apkd2
Polycystic Kidney Disease, Type 2	Adpkd2
Adult Polycystic Kidney Disease Type 2	Autosomal Dominant Polycystic Kidney Disease 2
Pkd-2	Polycystic Kidney Disease Adult Type Ii
Polycystic Kidney Type 2 Autosomal Dominant Disease	Kidney Disease, Polycystic, Type 2

Meckel Syndrome, Type 1

Meckel-Gruber Syndrome	Meckel Syndrome
Dysencephalia Splanchnocystica	Meckel Syndrome 1
MKS1	Mks
Gruber Syndrome	Meckel-Gruber Syndrome, Type 1
Mes	Dysencephalia Splachnocystica
Meckel Gruber Syndrome	Meckel Syndrome Type 1

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03522	DAND5 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	DAND5	VGNC	VGNC:71735
Canis familiaris	DAND5	VGNC	VGNC:39767
Felis catus	DAND5	VGNC	VGNC:102573
Rattus norvegicus	DAND5	RGD	RGD:1590249
Mus musculus	DAND5	MGD	MGI:1344365

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DAND5 - DAN domain BMP antagonist family member 5 Gene

关于 DAND5

功能概要

DAND5 基因产物(1)

DAND5 蛋白结构

关联疾病

直系同源

热门区域

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DAND5 - DAN domain BMP antagonist family member 5 Gene

关于 DAND5

功能概要

DAND5 基因产物(1)

DAND5 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z