2. Gene
  3. ELF5 - E74 like ETS transcription factor 5 Gene

ELF5 - E74 like ETS transcription factor 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：E74 样 ETS 转录因子 5

种属: Homo sapiens

同用名: ESE2

基因 ID: 2001 | 基因类型: protein coding

关于 ELF5

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:34,478,791-34,513,794 (from NCBI)

This gene has 7 transcripts (splice variants), 120 orthologues and 28 paralogues. Biased expression in salivary gland (RPKM 27.3), kidney (RPKM 9.7) and 2 other tissues.

功能概要

该基因编码上皮特异性 ETS 家族转录因子。除了它在调节角质形成细胞终末分化的后期阶段中的作用外，它似乎还调节在含有腺体上皮的组织 (例如唾液腺和前列腺) 中发现的许多上皮特异性基因。由于其氨基末端的负调控域，它对 DNA 的亲和力非常低。该基因被认为是乳腺癌中的肿瘤抑制转录因子。[RefSeq 提供，2022 年 5 月]

This gene encodes an epithelium-specific ETS family transcription factor. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. This gene has been implicated as a tumor suppressive transcription factor in breast Cancer. [provided by RefSeq, May 2022]

ELF5 基因产物(4)

mRNA Protein Name
NM_001243080.2 NP_001230009.1 ETS-related transcription factor Elf-5 isoform 3
NM_001243081.2 NP_001230010.1 ETS-related transcription factor Elf-5 isoform 4
NM_001422.4 NP_001413.1 ETS-related transcription factor Elf-5 isoform 2
NM_198381.2 NP_938195.1 ETS-related transcription factor Elf-5 isoform 1

ELF5 蛋白结构

SAM_PNT

SAM_PNT: Sterile alpha motif (SAM)/Pointed domain (47 - 128)

Ets

Ets: Ets-domain (174 - 255)

  • 0
  • 100
  • 200
  • 265 a.a.
蛋白主名 其他名称

ETS-related transcription factor Elf-5

E74-like factor 5 (ets domain transcription factor)

关联疾病

疾病名称 别名
Haemophilus Meningitis

Meningitis, Haemophilus
Down Syndrome

Trisomy 21

Complete Trisomy 21 Syndrome

Down'S Syndrome

Trisomy 21 Syndrome

Down'S Syndrome - Trisomy 21

Downs Syndrome

G Trisomy

47,Xx,+21

47,Xy,+21

Trisomy G

Down Syndrome, Susceptibility To

Chromosome 21 Trisomy

Trisomy 21 Nos

Abnormal Autosomes 21
Isolated Growth Hormone Deficiency, Type Ii

Ighd Ii

Isolated Growth Hormone Deficiency Type Ii

IGHD2

Growth Hormone Deficiency, Isolated, Type Ii

Congenital Ighd Type Ii

Congenital Isolated Gh Deficiency Type Ii

Congenital Isolated Growth Hormone Deficiency Type Ii

Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency Autosomal Dominant

Growth Hormone Deficiency, Isolated, Autosomal Dominant

Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency, Autosomal Dominant

Autosomal Dominant Isolated Growth Hormone Deficiency

Autosomal Dominant Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency

Isolated Growth Hormone Deficiency Type 2

Growth Hormone Deficiency, Isolated Autosomal Dominant

Growth Hormone Deficiency, Isolated, 2

Growth Hormone Deficiency Isolated Autosomal Dominant
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04302 ELF5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ELF5 RGD RGD:1305859
Bos taurus ELF5 VGNC VGNC:28430
Canis familiaris ELF5 VGNC VGNC:40302
Mus musculus ELF5 MGD MGI:1335079
Felis catus ELF5 VGNC VGNC:61809
Macaca mulatta ELF5 VGNC VGNC:72209
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