2. Gene
  3. Kmt2a - lysine (K)-specific methyltransferase 2A Gene

Kmt2a - lysine (K)-specific methyltransferase 2A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: HRX; Mll; All1; Mll1; ALL-1; Cxxc7; HTRX1; mKIAA4050; 6430520K01

基因 ID: 214162 | 基因类型: protein coding

关于 Kmt2a

功能概要

Enables DNA binding activity; chromatin binding activity; and Histone Methyltransferase activity (H3-K4 specific). Involved in several processes, including definitive hemopoiesis; regulation of gene expression; and regulation of histone modification. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; macromolecule methylation; and regulation of histone modification. Located in nucleus. Is expressed in several structures, including extraembryonic component; genitourinary system; hematopoietic system; nervous system; and retina. Used to study acute lymphoblastic leukemia and acute myeloid leukemia. Human ortholog(s) of this gene implicated in acute myeloid leukemia; cervical cancer; mixed phenotype acute leukemia; and non-Hodgkin lymphoma. Orthologous to human KMT2A (lysine methyltransferase 2A). [provided by Alliance of Genome Resources, Apr 2022]

Kmt2a 基因产物(1)

mRNA Protein Name
NM_001357549.2 NP_001344478.1 histone-lysine N-methyltransferase 2A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
24824656 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
15640349 MGI
enables histone H3K4 methyltransferase activity IDA
IDA: 通过直接分析推断
12453418 MGI
enables histone H3K4 methyltransferase activity IMP
IMP: 通过突变表型推断
16618927 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16618927 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within anterior/posterior pattern specification IGI
IGI: 通过遗传相互作用推断
15741318 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: 通过突变表型推断
16618927 MGI
involved in circadian regulation of gene expression IMP
IMP: 通过突变表型推断
21113167 MGI
acts upstream of or within cognition IMP
IMP: 通过突变表型推断
25834037 MGI
involved in definitive hemopoiesis IMP
IMP: 通过突变表型推断
15556871 MGI
acts upstream of or within embryonic hemopoiesis IMP
IMP: 通过突变表型推断
9639506 MGI
acts upstream of or within epigenetic regulation of gene expression IMP
IMP: 通过突变表型推断
16618927 MGI
acts upstream of or within exploration behavior IMP
IMP: 通过突变表型推断
25834037 MGI
acts upstream of fibroblast proliferation IMP
IMP: 通过突变表型推断
15640349 MGI
acts upstream of or within homeostasis of number of cells within a tissue IGI
IGI: 通过遗传相互作用推断
22674806 MGI
acts upstream of or within negative regulation of fibroblast proliferation IMP
IMP: 通过突变表型推断
15640349 MGI
acts upstream of or within peptidyl-lysine monomethylation IMP
IMP: 通过突变表型推断
25834037 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
21113167 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
15640349 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
12453418 MGI
acts upstream of or within post-embryonic development IGI
IGI: 通过遗传相互作用推断
22674806 MGI
acts upstream of or within regulation of gene expression IMP
IMP: 通过突变表型推断
25834037 MGI
acts upstream of or within regulation of short-term neuronal synaptic plasticity IMP
IMP: 通过突变表型推断
25834037 MGI
acts upstream of or within response to light stimulus IMP
IMP: 通过突变表型推断
25834037 MGI
acts upstream of or within spleen development IGI
IGI: 通过遗传相互作用推断
22674806 MGI
acts upstream of or within visual learning IMP
IMP: 通过突变表型推断
25834037 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
11555636 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

histone-lysine N-methyltransferase 2A

cysteine methyltransferase KMT2A

histone-lysine N-methyltransferase MLL

myeloid/lymphoid or mixed-lineage leukemia protein 1

trithorax Drosophila

zinc finger protein HRX

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-148669 Bleximenib 99.36% Phase 2
HY-148669A Bleximenib oxalate 98.0% Phase 2
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148669B (S)-Bleximenib oxalate Control 98.37% 否
HY-170832 Menin–KMT2A-IN-1 Inhibitor / 否
HY-RS07401 KMT2A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18528 Kmt2a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25010 Kmt2a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Kmt2a NCBI NCBI:4297
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