2. Gene
  3. Thbs1 - thrombospondin 1 Gene

Thbs1 - thrombospondin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: TSP1; TSP-1; tbsp1; Thbs-1

基因 ID: 21825 | 基因类型: protein coding

关于 Thbs1

功能概要

The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V Collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Thbs1 基因产物(2)

mRNA Protein Name
NM_001313914.1 NP_001300843.1 thrombospondin-1 isoform 2 precursor
NM_011580.4 NP_035710.2 thrombospondin-1 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables extracellular matrix binding IDA
IDA: 通过直接分析推断
18757743 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
22682248 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in behavioral response to pain IMP
IMP: 通过突变表型推断
22745497 MGI
acts upstream of or within blood vessel morphogenesis IGI
IGI: 通过遗传相互作用推断
20026598 MGI
acts upstream of or within cellular response to nitric oxide IMP
IMP: 通过突变表型推断
16150726 MGI
acts upstream of or within endocardial cushion development IGI
IGI: 通过遗传相互作用推断
20026598 MGI
acts upstream of or within growth plate cartilage development IGI
IGI: 通过遗传相互作用推断
18467703 MGI
acts upstream of or within growth plate cartilage development IMP
IMP: 通过突变表型推断
18467703 MGI
acts upstream of or within inflammatory response IMP
IMP: 通过突变表型推断
15963261 MGI
acts upstream of or within monocyte aggregation IMP
IMP: 通过突变表型推断
28228282 MGI
acts upstream of or within negative regulation of angiogenesis IDA
IDA: 通过直接分析推断
12498716 MGI
acts upstream of or within negative regulation of angiogenesis IMP
IMP: 通过突变表型推断
16150726 MGI
acts upstream of or within negative regulation of endothelial cell proliferation IMP
IMP: 通过突变表型推断
16150726 MGI
acts upstream of or within outflow tract morphogenesis IGI
IGI: 通过遗传相互作用推断
20026598 MGI
acts upstream of or within positive regulation of cell-substrate adhesion IDA
IDA: 通过直接分析推断
18757743 MGI
involved in positive regulation of macrophage chemotaxis IMP
IMP: 通过突变表型推断
18757424 MGI
involved in positive regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
9657149 MGI
involved in response to endoplasmic reticulum stress IMP
IMP: 通过突变表型推断
22682248 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
22682248 MGI
located in extracellular matrix IDA
IDA: 通过直接分析推断
18285447 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
12498716 MGI
located in sarcoplasmic reticulum IDA
IDA: 通过直接分析推断
22682248 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

thrombospondin-1

glycoprotein G

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14479 THBS1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16903 Thbs1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23345 Thbs1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Thbs1 NCBI NCBI:7057
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