1. Gene
  2. ADGRL1 - adhesion G protein-coupled receptor L1 Gene

ADGRL1 - adhesion G protein-coupled receptor L1 Gene

中文名称:粘附 G 蛋白偶联受体 L1

种属: Homo sapiens

同用名: CL1; LEC2; CIRL1; LPHN1; DEDBANP

基因 ID: 22859 | 基因类型: protein coding

关于 ADGRL1

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,147,743-14,206,169 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 211 orthologues and 42 paralogues. Broad expression in brain (RPKM 19.5), fat (RPKM 7.9) and 22 other tissues.

功能概要

该基因编码 G 蛋白偶联受体 (GPCR) 的 latrophilin 亚家族成员。 Latrophilins 可能在细胞粘附和信号转导中发挥作用。在非人类物种的实验中,富含半胱氨酸的 GPS (G 蛋白偶联受体蛋白水解位点) 结构域内的内源性蛋白水解切割产生两个亚基 (一个大的细胞外 N 末端细胞粘附亚基和一个与 GPCR 的分泌素/降钙素家族) 非共价结合在细胞膜上。 Latrophilin-1 已被证明可以将黑寡妇蜘蛛毒液中的神经毒素 alpha-latrotoxin 募集到突触质膜。可变剪接导致编码不同异构体的多个变体。[RefSeq 提供,2008 年 10 月]

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/Calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

ADGRL1 基因产物(2)

mRNA Protein Name
NM_001008701.3 NP_001008701.1 adhesion G protein-coupled receptor L1 isoform 1 precursor
NM_014921.5 NP_055736.2 adhesion G protein-coupled receptor L1 isoform 2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21078624 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ADGRL1 蛋白结构

Gal_Lectin

Gal_Lectin: Galactose binding lectin domain (48 - 128)

OLF

OLF: Olfactomedin-like domain (144 - 397)

HRM

HRM: Hormone receptor domain (478 - 534)

(542 - 775)

GPS

GPS: GPCR proteolysis site, GPS, motif (799 - 845)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (859 - 1093)

Latrophilin

Latrophilin: Latrophilin Cytoplasmic C-terminal region (1113 - 1474)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1474 a.a.
蛋白主名 其他名称

adhesion G protein-coupled receptor L1

CIRL-1

关联疾病

疾病名称 别名
Developmental Delay, Behavioral Abnormalities, And Neuropsychiatric Disorders

DEDBANP

Specific Learning Disability

Specific Learning Difficulty

Specific Learning Disorder

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

Loiasis

Loa Loa Filariasis

Mansonelliasis

African Eye Worm

Mansonella Perstans Infections

Mansonellosis

Eye Worm Disease Of Africa

Loa Loa Infestation

African Eyeworm Disease

Calabar Swelling

Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria

BFPP

Cerebellar Ataxia With Neuronal Migration Defect

Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation

CDG1N

Congenital Disorders Of Glycosylation

Cdg In

Cdgin

Congenital Disorder Of Glycosylation 1n

Carbohydrate-Deficient Glycoprotein Syndrome

Cdg

Rft1-Cdg

Cdg-In

Congenital Disorder Of Glycosylation Type In

Carbohydrate Deficient Glycoprotein Syndrome

Cdg Syndrome

Congenital Disorder Of Glycosylation In

Carbohydrate-Deficient Glycoprotein Syndromes

Cdg Syndrome Type In

Carbohydrate Deficient Glycoprotein Syndrome Type In

Congenital Disorder Of Glycosylation Type 1n

Man5glcnac2-Pp-Dol Flippase Deficiency

Glycosylation, Congenital Disorder Of

Glycosylation, Congenital Disorder Of, Type In

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus ADGRL1 VGNC VGNC:59638
Mus musculus ADGRL1 MGD MGI:1929461
Rattus norvegicus ADGRL1 RGD RGD:620768
Canis familiaris ADGRL1 VGNC VGNC:37650
Macaca mulatta ADGRL1 VGNC VGNC:69658
Bos taurus ADGRL1 VGNC VGNC:25671