2. Gene
  3. DTX4 - deltex E3 ubiquitin ligase 4 Gene

DTX4 - deltex E3 ubiquitin ligase 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：deltex E3 泛素连接酶 4

种属: Homo sapiens

同用名: RNF155

基因 ID: 23220 | 基因类型: protein coding

关于 DTX4

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:59,171,430-59,208,588 (from NCBI)

This gene has 4 transcripts (splice variants), 284 orthologues and 4 paralogues. Ubiquitous expression in urinary bladder (RPKM 13.0), lung (RPKM 11.7) and 25 other tissues.

功能概要

预测可启用泛素蛋白连接酶活性。预计参与 Notch 信号通路和蛋白质泛素化。预测位于胞质溶胶中。预计在核质中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable ubiquitin protein Ligase activity. Predicted to be involved in Notch signaling pathway and protein ubiquitination. Predicted to be located in cytosol. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DTX4 基因产物(2)

mRNA Protein Name
NM_001300727.2 NP_001287656.1 E3 ubiquitin-protein ligase DTX4 isoform 2
NM_015177.2 NP_055992.1 E3 ubiquitin-protein ligase DTX4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
35793002 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of innate immune response IDA
IDA: 通过直接分析推断
27692986 GOA
involved in proteasomal protein catabolic process IDA
IDA: 通过直接分析推断
35793002 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
27692986 GOA
involved in protein K48-linked ubiquitination IDA
IDA: 通过直接分析推断
27692986 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in centrosome IDA
IDA: 通过直接分析推断
35793002 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DTX4 蛋白结构

WWE

WWE: WWE domain (3 - 78)

WWE

WWE: WWE domain (85 - 155)

zf-RING_2

zf-RING_2: Ring finger domain (408 - 468)

  • 0
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  • 500
  • 619 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase DTX4

RING finger protein 155

关联疾病

疾病名称 别名
Cutaneous Diphtheria

Diphtheria Wound Infection
Congenital Anomalies Of Kidney And Urinary Tract 2

CAKUT2

Ureteropelvic Junction Obstruction

Multicystic Renal Dysplasia, Bilateral

Pelviureteric Junction Obstruction

Pujo

Hydronephrosis Due To Pujo

Upjo

Mcrd

Congenital Anomalies Of The Kidney And Urinary Tract 2

Mrd

Pelvi-Ureteric Junction Obstruction

Kidney And Urinary Tract, Anomalies, Congenital, Type 2

Obstruction Of Pelviureteric Junction
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04042 DTX4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21330 Dtx4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27849 Dtx4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus DTX4 MGD MGI:2672905
Felis catus DTX4 VGNC VGNC:102876
Rattus norvegicus DTX4 RGD RGD:1311767
Canis familiaris DTX4 VGNC VGNC:40119
Bos taurus DTX4 VGNC VGNC:54867
Macaca mulatta DTX4 VGNC VGNC:71929
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