Htr1a - 5-hydroxytryptamine receptor 1A Gene

中文名称：5-羟色胺受体 1A

种属: Rattus norvegicus

同用名: 5HT1A; RAT5HT1A

关于 Htr1a

功能概要

该基因编码的蛋白可启动多种功能，包括 G 蛋白偶联血清素受体活性； G蛋白α-亚基结合活性；和血清素结合活性。参与多个过程，包括 NMDA 谷氨酸受体聚类；腺苷酸环化酶抑制血清素受体信号通路；和分泌调节。位于轴突岗。在 GABA 能突触中活跃。是突触前膜的组成部分。用于研究帕金森病和恐慌症。该基因的人类直系同源物与焦虑症有关；精神抑郁症；和恐慌症。与人类 HTR1A（5-羟色胺受体 1A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including G protein-coupled serotonin receptor activity; G-protein alpha-subunit binding activity; and serotonin binding activity. Involved in several processes, including NMDA glutamate receptor clustering; adenylate cyclase-inhibiting serotonin receptor signaling pathway; and regulation of secretion. Located in axon hillock. Is active in GABA-ergic synapse. Is integral component of presynaptic membrane. Used to study Parkinson's disease and panic disorder. Human ortholog(s) of this gene implicated in anxiety disorder; mental depression; and panic disorder. Orthologous to human HTR1A (5-hydroxytryptamine receptor 1A). [provided by Alliance of Genome Resources, Apr 2022]