2. Gene
  3. Ide - insulin degrading enzyme Gene

Ide - insulin degrading enzyme Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: INSDEGM

基因 ID: 25700 | 基因类型: protein coding

关于 Ide

功能概要

Enables several functions, including ATP binding activity; ATP hydrolysis activity; and peptide binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; amyloid-beta metabolic process; and negative regulation of proteolysis. Located in several cellular components, including cell surface; extracellular space; and peroxisomal matrix. Part of cytosolic Proteasome complex. Used to study Alzheimer's disease and type 2 diabetes mellitus. Biomarker of Alzheimer's disease and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IDE (Insulin degrading enzyme). [provided by Alliance of Genome Resources, Apr 2022]

Ide 基因产物(1)

mRNA Protein Name
NM_013159.2 NP_037291.1 insulin-degrading enzyme
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IMP
IMP: 通过突变表型推断
15749695 RGD
enables ATP binding IPI
IPI: 通过物理相互作用推断
17259336 RGD
enables ATP hydrolysis activity IDA
IDA: 通过直接分析推断
17259336 RGD
enables amyloid-beta binding IPI
IPI: 通过物理相互作用推断
18411275 RGD
enables beta-endorphin binding IMP
IMP: 通过突变表型推断
15749695 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
15494400 RGD
enables insulin binding IMP
IMP: 通过突变表型推断
15749695 RGD
enables metalloendopeptidase activity IDA
IDA: 通过直接分析推断
15494400 RGD
enables metalloendopeptidase activity IMP
IMP: 通过突变表型推断
15749695 RGD
enables peptide hormone binding IPI
IPI: 通过物理相互作用推断
15494400 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
9000694 RGD
enables zinc ion binding IMP
IMP: 通过突变表型推断
15749695 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in amyloid-beta clearance IGI
IGI: 通过遗传相互作用推断
19406747 RGD
involved in amyloid-beta clearance IMP
IMP: 通过突变表型推断
10684867 RGD
involved in amyloid-beta clearance by cellular catabolic process IMP
IMP: 通过突变表型推断
18941241 RGD
involved in amyloid-beta metabolic process IMP
IMP: 通过突变表型推断
15749695 RGD
involved in hormone catabolic process IDA
IDA: 通过直接分析推断
15494400 RGD
involved in negative regulation of proteolysis IDA
IDA: 通过直接分析推断
9000694 RGD
involved in protein catabolic process IDA
IDA: 通过直接分析推断
11235899 RGD
involved in proteolysis involved in protein catabolic process IMP
IMP: 通过突变表型推断
15749695 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
10684867 RGD
part of cytosolic proteasome complex IDA
IDA: 通过直接分析推断
9000694 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
10684867 RGD
located in peroxisomal matrix IDA
IDA: 通过直接分析推断
11235899 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

insulin-degrading enzyme

insulin protease

insulinase

insulysin

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-101569 Darovasertib Inhibitor 99.18% Phase 2
Pre-clinical Phase
生物活性分子 (17)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100533 IDE1 98.51% 否
HY-N7135 Tropolone Inhibitor 99.93% 否
HY-100534 IDE 2 Agonist 99.00% 否
HY-110197 6bK TFA 99.35% 否
HY-117878 ML345 Inhibitor 99.37% 否
HY-169422 GSK4418959 Inhibitor 98.72% 否
HY-W157689 IDE-IN-2 Inhibitor 98.04% 否
HY-114611 BDM44768 / 否
HY-12655 IDE-IN-1 Inhibitor / 否
HY-143401 Hit 1 Activator / 否
HY-169422A GSK4418959 (enantiomer) / 否
HY-176347S Alpha Feto Protein, Arg-13C6,15N4, Lys-13C6,15N2 / 否
HY-RS06526 IDE Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W616806 Sodium 6-oxo-3,6-dihydropurin-7-ide / 否
HY-Y0424AS Potassium 1,3-dioxoisoindolin-2-ide-15N / 否
HY-RS16920 Ide Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23363 Ide Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ide NCBI NCBI:3416
Canis familiaris Ide NCBI NCBI:477768
Macaca fascicularis Ide NCBI NCBI:102128252
Mus musculus Ide NCBI NCBI:15925
Susscrofa domestica Ide NCBI
Macaca mulatta Ide NCBI NCBI:698640
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z