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  2. NOCT - nocturnin Gene

NOCT - nocturnin Gene

中文名称:夜曲素

种属: Homo sapiens

同用名: NOC; CCR4L; Ccr4c; CCRN4L

基因 ID: 25819 | 基因类型: protein coding

关于 NOCT

Cytogenetic location: 4q31.1 Genomic coordinates (GRCh38): 4:139,015,781-139,045,939 (from NCBI)

This gene has 3 transcripts (splice variants), 264 orthologues and 5 paralogues. Broad expression in bone marrow (RPKM 15.3), liver (RPKM 6.4) and 18 other tissues.

功能概要

该基因编码的蛋白质与 Nocturnin 高度相似,Nocturnin 是非洲爪蟾中被鉴定为生物钟调节基因的基因。这种蛋白质和 Nocturnin 蛋白质与酵母转录因子碳分解代谢物抑制 4 (CCR4) 的 C 末端结构域具有相似性。小鼠中相似基因的 mRNA 丰度已显示出昼夜节律性,这表明该蛋白质在时钟功能或作为生物钟效应器中的作用。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector. [provided by RefSeq, Jul 2008]

NOCT 基因产物(1)

mRNA Protein Name
NM_012118.4 NP_036250.2 nocturnin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NADP phosphatase activity IDA
IDA: 通过直接分析推断
31147539 GOA
enables NADPH phosphatase activity IDA
IDA: 通过直接分析推断
31147539 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in NADP metabolic process IDA
IDA: 通过直接分析推断
31147539 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrion IDA
IDA: 通过直接分析推断
31147539 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NOCT 蛋白结构

Exo_endo_phos

Exo_endo_phos: Endonuclease/Exonuclease/phosphatase family (146 - 414)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 431 a.a.
蛋白主名 其他名称

nocturnin

CCR4 carbon catabolite repression 4-like

直系同源

种属 基因名 来源 基因 ID
Canis familiaris NOCT VGNC VGNC:43876
Mus musculus NOCT MGD MGI:109382
Felis catus NOCT VGNC VGNC:63848
Bos taurus NOCT VGNC VGNC:32149
Rattus norvegicus NOCT RGD RGD:1587344
Macaca mulatta NOCT VGNC VGNC:100256
Others NOCT NCBI