2. Gene
  3. KRT23 - keratin 23 Gene

KRT23 - keratin 23 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：角蛋白 23

种属: Homo sapiens

同用名: K23; CK23; HAIK1

基因 ID: 25984 | 基因类型: protein coding

关于 KRT23

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:40,922,700-40,937,646 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 119 orthologues and 68 paralogues. Biased expression in placenta (RPKM 45.8), skin (RPKM 39.5) and 7 other tissues.

功能概要

该基因编码的蛋白质是角蛋白家族的一员。角蛋白是负责上皮细胞结构完整性的中间丝蛋白，可细分为细胞角蛋白和毛发角蛋白。 I 型细胞角蛋白由排列成对异型角蛋白链的酸性蛋白组成。 I 型细胞角蛋白基因聚集在染色体 17q12-q21 的区域。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 9 月]

The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

KRT23 基因产物(2)

mRNA Protein Name
NM_001282433.2 NP_001269362.1 keratin, type I cytoskeletal 23 isoform 2
NM_015515.5 NP_056330.3 keratin, type I cytoskeletal 23 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KRT23 蛋白结构

Filament

Filament: Intermediate filament protein (71 - 380)

  • 0
  • 100
  • 200
  • 300
  • 422 a.a.
蛋白主名 其他名称

keratin, type I cytoskeletal 23

CK-23

关联疾病

疾病名称 别名
Transitional Papilloma

Transitional Cell Papilloma

Transitional Cell Papilloma, Benign
Van Den Ende-Gupta Syndrome

VDEGS

Blepharophimosis, Arachnodactyly, And Congenital Contractures

Marden-Walker-Like Syndrome

Marden-Walker-Like Syndrome Without Psychomotor Retardation

Marden Walker Like Syndrome

Marden-Walker-Like Syndrome Without Psychmotor Retardation

Van Den Ende Gupta Syndrome

Marden Walker Like Syndrome Without Psychomotor Retardation

Blepharophimosis Arachnodactyly And Congenital Contractures
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07447 KRT23 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta KRT23 VGNC VGNC:74211
Canis familiaris KRT23 VGNC VGNC:42522
Rattus norvegicus KRT23 RGD RGD:1308838
Felis catus KRT23 VGNC VGNC:67987
Mus musculus KRT23 MGD MGI:2148866
Bos taurus KRT23 VGNC VGNC:30722
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