2. Gene
  3. Sptlc1 - serine palmitoyltransferase, long chain base subunit 1 Gene

Sptlc1 - serine palmitoyltransferase, long chain base subunit 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Lcb1; SPT1; E030036H05

基因 ID: 268656 | 基因类型: protein coding

关于 Sptlc1

功能概要

Enables serine C-palmitoyltransferase activity. Involved in regulation of fat cell apoptotic process and sphingomyelin biosynthetic process. Acts upstream of or within ceramide biosynthetic process; sphinganine biosynthetic process; and sphingosine biosynthetic process. Located in endoplasmic reticulum membrane. Is expressed in brain and liver. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 1A. Orthologous to human SPTLC1 (serine palmitoyltransferase long chain base subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Sptlc1 基因产物(1)

mRNA Protein Name
NM_009269.2 NP_033295.2 serine palmitoyltransferase 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18484747 MGI
NOT enables serine C-palmitoyltransferase activity IDA
IDA: 通过直接分析推断
9363775 MGI
enables serine C-palmitoyltransferase activity IMP
IMP: 通过突变表型推断
28100772 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within ceramide biosynthetic process IMP
IMP: 通过突变表型推断
16216550 MGI
involved in regulation of fat cell apoptotic process IMP
IMP: 通过突变表型推断
28100772 MGI
acts upstream of or within sphinganine biosynthetic process IMP
IMP: 通过突变表型推断
19416652 MGI
involved in sphingolipid metabolic process IMP
IMP: 通过突变表型推断
28100772 MGI
involved in sphingomyelin biosynthetic process IDA
IDA: 通过直接分析推断
26301690 MGI
acts upstream of or within sphingomyelin biosynthetic process IMP
IMP: 通过突变表型推断
16216550 MGI
acts upstream of or within sphingosine biosynthetic process IMP
IMP: 通过突变表型推断
16216550 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
26301690 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

serine palmitoyltransferase 1

long chain base biosynthesis protein 1

serine-palmitoyl-CoA transferase 1

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13736 SPTLC1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21943 Sptlc1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sptlc1 NCBI NCBI:10558
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