1. Gene
  2. Lig4 - DNA ligase 4 Gene

Lig4 - DNA ligase 4 Gene

种属: Rattus norvegicus

基因 ID: 290907 | 基因类型: protein coding

关于 Lig4

功能概要

Enables ATP binding activity; DNA binding activity; and DNA Ligase (ATP) activity. Involved in DNA ligation and cellular response to lithium ion. Located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including DNA Ligase IV deficiency; colorectal cancer; high grade glioma; multiple myeloma; and prostate Cancer. Orthologous to human LIG4 (DNA Ligase 4). [provided by Alliance of Genome Resources, Apr 2022]

Lig4 基因产物(1)

mRNA Protein Name
NM_001106095.1 NP_001099565.1 DNA ligase 4
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
9600082 RGD
enables DNA binding IDA
IDA: 通过直接分析推断
9600082 RGD
enables DNA ligase (ATP) activity IDA
IDA: 通过直接分析推断
9600082 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA ligation IDA
IDA: 通过直接分析推断
9600082 RGD
involved in cellular response to lithium ion IEP
IEP: 通过表达模式推断
19285016 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

DNA ligase 4

DNA ligase (ATP) 4

ligase IV, DNA, ATP-dependent

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lig4 NCBI NCBI:3981