2. Gene
  3. Ldlr - low density lipoprotein receptor Gene

Ldlr - low density lipoprotein receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: LDLRA

基因 ID: 300438 | 基因类型: protein coding

关于 Ldlr

功能概要

Enables low-density lipoprotein particle receptor activity. Involved in several processes, including Cholesterol homeostasis; positive regulation of triglyceride catabolic process; and response to glucagon. Located in caveola and recycling endosome membrane. Used to study atherosclerosis and xanthomatosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LDLR (low density lipoprotein receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ldlr 基因产物(1)

mRNA Protein Name
NM_175762.3 NP_786938.2 low-density lipoprotein receptor precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables low-density lipoprotein particle receptor activity IDA
IDA: 通过直接分析推断
3559401 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
15044370 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cholesterol homeostasis IEP
IEP: 通过表达模式推断
20028367 RGD
involved in endocytosis IMP
IMP: 通过突变表型推断
17256088 RGD
involved in positive regulation of triglyceride catabolic process IMP
IMP: 通过突变表型推断
28469073 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
3559401 RGD
involved in response to estrogen IEP
IEP: 通过表达模式推断
15044370 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
20028367 RGD
involved in response to glucagon IEP
IEP: 通过表达模式推断
19008317 RGD
involved in response to hormone IEP
IEP: 通过表达模式推断
17572141 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
18703410 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in caveola IDA
IDA: 通过直接分析推断
12646183 RGD
located in recycling endosome membrane IDA
IDA: 通过直接分析推断
10468577 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

low-density lipoprotein receptor

LDL receptor

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-106539 Colesevelam hydrochloride 98.00% 否
HY-B0374A Moxonidine hydrochloride 99.83% 否
HY-B0374 Moxonidine 99.72% 否
Clinical Phase
生物活性分子 (5)
目录号 产品名 作用方式
纯度 Phase
HY-P4073 ANG1005 98.83% Phase 3
HY-152857 Muvalaplin Inhibitor 99.96% Phase 2
HY-109567 Gemcabene Inhibitor 99.91% Phase 2
HY-109567A Gemcabene calcium Inhibitor ≥98.0% Phase 2
HY-116175 BIBB 515 99.44% Phase 1
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P99822 Recaticimab 99.71% Phase 4
HY-P99793 Orticumab Inhibitor ≥99.0% Phase 2
Pre-clinical Phase
生物活性分子 (42)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-NP013 Oxidized low density lipoprotein (mouse) 98.00% 否
HY-P2341 Angiopep-2 hydrochloride 99.74% 否
HY-W020017 Propanoic acid Inhibitor 99.50% 否
HY-W007347 1,2-Cyclohexanedione 98.68% 否
HY-145001 20-HC-Me-Pyrrolidine Inhibitor 99.69% 否
HY-101529 Imanixil 98.88% 否
HY-125544 LY 295427 Modulator ≥98.0% 否
HY-W015600 2-Acetamidophenol Inhibitor 99.61% 否
HY-NP012 Low density lipoprotein (human) / 否
HY-120651 LDL-IN-2 Inhibitor ≥99.0% 否
HY-P10697A VH4127 TFA Modulator / 否
HY-W020017R Propanoic acid (Standard) Inhibitor 99.69% 否
HY-A0127 Etofibrate Activator 99.80% 否
HY-100144 Pirozadil 98.31% 否
HY-U00054 LDL-IN-3 Inhibitor / 否
HY-P10697 VH4127 Modulator / 否
HY-W423578 LDLR regulator-1 Modulator / 否
HY-126551 Butenoyl-PAF / 否
HY-115914 Lipid-lowering agent-1 / 否
HY-P10502 L57 / 否
HY-N15706 Luteolin-7-O-β-D-glucuronide methyl ester / 否
HY-161941 MeIm / 否
HY-P10911 IETP2 Ligand / 否
HY-P10698 VH-N412 / 否
HY-167870 Piceatannol 4'-O-glucoside Inhibitor / 否
HY-172661 Kylo-0603 Inhibitor / 否
HY-147279 Milpocitide / 否
HY-176274 FASN/SCD-IN-1 Inhibitor / 否
HY-113288 Campestanol Inhibitor ≥99.0% 否
HY-167873 Habenariol Inhibitor / 否
HY-B0374S1 Moxonidine-d7 / 否
HY-175082 TBPH / 否
HY-P10697B H-PEG6-VH4127-NH2 / 否
HY-B0374AS Moxonidine-13C,d3 hydrochloride / 否
HY-B0374S2 Moxonidine-d3 / 否
HY-B0374S Moxonidine-d4 / 否
HY-161938 BRD8518 / 否
HY-159595 PCSK9-IN-29 Inducer 99.44% 否
HY-123260 S12340 Inhibitor / 否
HY-164412 Phosphatidylcholine (C18:2,C20:4) Activator / 否
HY-165512 Nicanartine Inhibitor / 否
HY-138089 17β-Hydroxy exemestane Inhibitor / 否
抗体抑制剂 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990202 Anti-Mouse/Rat/Human LRP1/CD91 Antibody (11H4) Inhibitor ≥95.0% 否
HY-P990143 Anti-Mouse/Rat/Bovine VLDL-R Antibody (IgG-6A6) Inhibitor 95.00% 否
HY-P990480 Anti-oxLDL Antibody / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ldlr NCBI NCBI:3949
Macaca fascicularis Ldlr NCBI NCBI:102127361
Mus musculus Ldlr NCBI NCBI:16835
Leporidae Ldlr NCBI
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