IGL - immunoglobulin lambda locus Gene

中文名称：免疫球蛋白λ位点

种属: Homo sapiens

同用名: IGL@; IGLC6

关于 IGL

功能概要

免疫球蛋白识别外来抗原并启动免疫反应，例如吞噬作用和补体系统。每个免疫球蛋白分子由两条相同的重链和两条相同的轻链组成。有两类轻链，kappa 和 lambda。该区域代表 lambda 轻链基因座的种系组织。基因座包括 V (可变) 、J (连接) 和 C (恒定) 片段。在 B 细胞发育过程中，DNA 水平的重组事件将单个 V 片段与 J 片段连接起来； C 段后来通过在 RNA 水平上的剪接连接。许多不同的 V 区段与几个 J 区段的重组提供了广泛的抗原识别。通过末端脱氧核苷酸转移酶随机添加核苷酸以及在脾脏和淋巴结中 B 细胞成熟期间发生的体细胞超突变，通过连接多样性获得额外的多样性。已知几个 V 区段和三个 C 区段不能编码蛋白质，被认为是假基因。该基因座还包括几个非免疫球蛋白基因，其中许多是假基因或通过自动计算分析或与其他物种的同源性预测。[RefSeq 提供，2008 年 7 月]

Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the Complement System. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V segments and three C segments are known to be incapable of encoding a protein and are considered pseudogenes. The locus also includes several non-immunoglobulin genes, many of which are pseudogenes or are predicted by automated computational analysis or homology to Other species. [provided by RefSeq, Jul 2008]