2. Gene
  3. Slc22a12 - solute carrier family 22 member 12 Gene

Slc22a12 - solute carrier family 22 member 12 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 22 成员 12

种属: Rattus norvegicus

同用名: Rst; URAT1; Slc22al2

基因 ID: 365398 | 基因类型: protein coding

关于 Slc22a12

Primary_assembly 1: 203,845,048-203,853,555 reverse strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 475 orthologues, 24 paralogues and is associated with 8 phenotypes. Restricted expression toward (RPKM 74.6).

功能概要

预测该基因编码的蛋白可启动 PDZ 结构域结合活性和尿酸盐跨膜转运蛋白活性。参与细胞对胰岛素刺激的反应；尿酸盐排泄；和尿酸盐运输。位于顶端质膜。糖尿病的生物标志物。与人类 SLC22A12 同源（溶质载体家族 22 成员 12）。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable PDZ domain binding activity and urate transmembrane transporter activity. Involved in cellular response to Insulin stimulus; urate salt excretion; and urate transport. Located in apical plasma membrane. Biomarker of diabetes mellitus. Orthologous to human SLC22A12 (solute carrier family 22 member 12). [provided by Alliance of Genome Resources, Apr 2022]

Slc22a12 基因产物(1)

mRNA Protein Name
NM_001034943.1 NP_001030115.1 solute carrier family 22 member 12
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to insulin stimulus IEP
IEP: 通过表达模式推断
28679589 RGD
involved in renal urate salt excretion IEP
IEP: 通过表达模式推断
28679589 RGD
involved in urate transport IDA
IDA: 通过直接分析推断
21074513 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
21074513 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Slc22a12 蛋白结构

MFS_OAT

MFS_OAT: cd17374 (108 - 540)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 578 a.a.
蛋白主名 其他名称

solute carrier family 22 member 12

solute carrier family 22 (organic anion/cation transporter), member 12

solute carrier family 22 (organic anion/urate transporter), member 12

solute carrier family 22 (organic cation transporter)-like 2

urate anion exchanger 1

urate:anion antiporter SLC22A12

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-173231 hURAT1 inhibitor 2 Inhibitor / 否
HY-RS13063 SLC22A12 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS13064 Slc22a12 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS13065 Slc22a12 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Slc22a12 NCBI NCBI:116085
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