2. Gene
  3. Nlrp12 - NLR family, pyrin domain containing 12 Gene

Nlrp12 - NLR family, pyrin domain containing 12 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Nalp12; PYPAF7; monarch-1

基因 ID: 378425 | 基因类型: protein coding

关于 Nlrp12

功能概要

Predicted to enable ATP binding activity. Involved in negative regulation of inflammatory response. Acts upstream of or within cellular response to cytokine stimulus; dendritic cell migration; and negative regulation of intracellular signal transduction. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 2. Orthologous to human NLRP12 (NLR family pyrin domain containing 12). [provided by Alliance of Genome Resources, Apr 2022]

Nlrp12 基因产物(1)

mRNA Protein Name
NM_001033431.1 NP_001028603.1 NACHT, LRR and PYD domains-containing protein 12
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22503542 MGI
enables protein-macromolecule adaptor activity IDA
IDA: 通过直接分析推断
22503542 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
22503542 MGI
acts upstream of or within cellular response to cytokine stimulus IMP
IMP: 通过突变表型推断
20861349 MGI
acts upstream of or within dendritic cell migration IMP
IMP: 通过突变表型推断
20861349 MGI
acts upstream of or within negative regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
22503542 MGI
involved in negative regulation of inflammatory response IMP
IMP: 通过突变表型推断
30212649 MGI
involved in negative regulation of non-canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
22503542 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

NACHT, LRR and PYD domains-containing protein 12

PYRIN-containing APAF1-like protein 7

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09352 NLRP12 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21166 Nlrp12 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27682 Nlrp12 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nlrp12 NCBI NCBI:91662
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