ARHGAP6 - Rho GTPase activating protein 6 Gene

中文名称：Rho GTP 酶激活蛋白 6

种属: Homo sapiens

同用名: RHOGAP6; RHOGAPX-1

基因 ID: 395 | 基因类型: protein coding

关于 ARHGAP6

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:11,137,544-11,665,920 (from NCBI)

This gene has 9 transcripts (splice variants), 269 orthologues and 1 paralogue. Broad expression in prostate (RPKM 12.6), thyroid (RPKM 10.2) and 18 other tissues.

功能概要

该基因编码 rhoGAP 蛋白家族的一个成员，该蛋白在多个细胞过程中在调节质膜上的肌动蛋白聚合中发挥作用。这种蛋白质被认为具有两个独立的功能，一个是对 RhoA 具有特异性的 GTP 酶激活蛋白，另一个是促进肌动蛋白重塑的细胞骨架蛋白。已为该基因发现编码不同亚型的多个可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ARHGAP6 基因产物(4)

mRNA	Protein	Name
NM_001287242.2	NP_001274171.1	rho GTPase-activating protein 6 isoform 6
NM_006125.3	NP_006116.2	rho GTPase-activating protein 6 isoform 3
NM_013423.3	NP_038267.1	rho GTPase-activating protein 6 isoform 4
NM_013427.3	NP_038286.2	rho GTPase-activating protein 6 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables phospholipase activator activity	IDA IDA: 通过直接分析推断	18434237	GOA
enables phospholipase binding	IPI IPI: 通过物理相互作用推断	18434237	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of focal adhesion assembly	IMP IMP: 通过突变表型推断	10699171	GOA
involved in negative regulation of stress fiber assembly	IMP IMP: 通过突变表型推断	10699171	GOA
involved in positive regulation of phospholipase activity	IDA IDA: 通过直接分析推断	18434237	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IMP IMP: 通过突变表型推断	10699171	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARHGAP6 蛋白结构

RhoGAP

0
200
400
600
800
974 a.a.

蛋白主名

其他名称

rho GTPase-activating protein 6

Rho-type GTPase-activating protein RhoGAPX-1

关联疾病

疾病名称

别名

Amelogenesis Imperfecta, Type Ie

Aih1	Amelogenesis Imperfecta Type 1e
AI1E	Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 1
Amelogenesis Imperfecta, Hypomaturation Type, With Snow-Capped Teeth	Enamel Hypoplasia, X-Linked
Amelogenesis Imperfecta Type Ie	Amelogenesis Imperfecta Hypoplastic/Hypomaturation X-Linked 1
Enamel Hypoplasia X-Linked	Amelogenesis Imperfecta, X-Linked 1
Amelogenesis Imperfecta, Type 1e	Amelogenesis Imperfecta Hypomaturationtype With Snow-Capped Teeth
X-Linked Amelogenesis Imperfecta 1	X-Linked Amelogenesis Imperfecta Hypoplastic/Hypomaturation 1
X-Linked Enamel Hypoplasia	Amelogenesis Imperfecta X-Linked 1
Amelogenesis Imperfecta 1e	Amelogenesis Imperfecta, Hypoplastic/Hypomaturation Type 1e
Amelogenesis Imperfecta Hypomaturation Type With Snow-Capped Teeth	Xai
X-Linked Amelogenesis Imperfecta	Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 2

Amelogenesis Imperfecta

Ai	Congenital Enamel Hypoplasia
Al - [Amelogenesis Imperfecta]

Linear Skin Defects With Multiple Congenital Anomalies 1

Midas Syndrome	Mcops7
Mls Syndrome	Microphthalmia, Syndromic 7
Microphthalmia With Linear Skin Defects Syndrome	Microphthalmia With Linear Skin Defects
Microphthalmia-Dermal Aplasia-Sclerocornea Syndrome	Syndromic Microphthalmia Type 7
LSDMCA1	Mls
Microphthalmia, Dermal Aplasia, And Sclerocornea	Microphthalmia With Linear Skin Defect Syndrome
Syndromic Microphthalmia 7	Linear Skin Defects With Multiple Congenital Anomalies
Microphthalmia, Dermal Aplasia, Sclerocornea Syndrome	Microphthalmia Dermal Aplasia And Sclerocornea Syndrome
Micropthalmia Syndromic 7	Microphthalmia Syndromic 7
Microphthalmia With Linear Skin Lesions Syndrome	Syndromic Microphthalmia-7
Microphthalmia, Dermal Aplasia And Sclerocornea	Microphthalmia, Syndromic, 7
Midas

Microphthalmia

Microphthalmos	Isolated Anophthalmia-Microphthalmia Syndrome
Isolated Microphthalmia-Anophthalmia-Coloboma	Simple Microphthalmos
Clinical Anophthalmia	Isolated Anophthalmia - Microphthalmia
Isolated Pure Microphthalmia	Mac Spectrum
Microphthalmia-Anophthalmia-Coloboma Spectrum	Primitive Anophthalmia
Globe Of Eye Small	Small Eyeball
Hypoplasia Of Eye	Isolated Nanophthalmos
Rudimentary Eye	Dysplasia Of Eye

Linear Skin Defects With Multiple Congenital Anomalies 3

LSDMCA3	Linear Skin Defects With Cardiomyopathy And Other Congenital Anomalies
Skin Defects, Linear, With Multiple Congenital Anomalies, Type 3

Orbital Cyst

Sclerocornea

Isolated Congenital Sclerocornea

Diffuse Gastric Cancer

Hereditary Diffuse Gastric Adenocarcinoma	Hereditary Diffuse Gastric Cancer
Signet Cell Adenocarcinoma	Signet Ring Cell Carcinoma
Signet Ring Cell Gastric Carcinoma	Signet Ring Gastric Carcinoma
Fdgc	Familial Diffuse Cancer Of Stomach
Familial Diffuse Gastric Cancer	Gastric Cancer, Familial Diffuse
Gastric Cancer, Hereditary Diffuse	Hdgc
Hereditary Diffuse Cancer Of Stomach	Diffuse Gastric Cancer Syndrome
Cancer, Gastric, Diffuse	Carcinoma, Signet Ring Cell
Gastric Signet Ring Carcinoma

Diffuse Gastric And Lobular Breast Cancer Syndrome

Hereditary Diffuse Gastric Cancer	HDGC
LBC	Familial Diffuse Gastric Cancer
Fdgc	Hereditary Diffuse Gastric Adenocarcinoma
Breast Cancer, Lobular	Gastric Cancer, Familial Diffuse, And Cleft Lip With Or Without Cleft Palate
DGLBC	Gastric Cancer, Hereditary Diffuse
Gastric Cancer, Familial Diffuse Breast Cancer, Lobular	Diffuse Gastric And Lobular Breast Cancer Syndrome With Or Without Cleft Lip And/Or Palate
E-Cadherin-Associated Hereditary Gastric Cancer	Familial Diffuse Cancer Of Stomach
Hereditary Diffuse Cancer Of Stomach	Gastric Cancer Familial Diffuse
Gastric Cancer Familial Diffuse And Cleft Lip With Or Without Cleft Palate	Cancer, Gastric, Hereditary Diffuse

Gillespie Syndrome

GLSP	Aniridia, Cerebellar Ataxia And Mental Deficiency
Aniridia Cerebellar Ataxia Mental Deficiency	Aniridia, Cerebellar Ataxia, And Mental Retardation
Aniridia-Cerebellar Ataxia-Intellectual Disability Syndrome	Aniridia-Cerebellar Ataxia-Intellectual Disability
Aniridia-Cerebellar Ataxia-Mental Deficiency	Partial Aniridia-Cerebellar Ataxia-Oligophrenia
Aniridia, Cerebellar Ataxia, And Intellectual Disability

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00940	ARHGAP6 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	ARHGAP6	MGD	MGI:1196332
Bos taurus	ARHGAP6	VGNC	VGNC:26099
Canis familiaris	ARHGAP6	VGNC	VGNC:38068
Macaca mulatta	ARHGAP6	VGNC	VGNC:70009
Felis catus	ARHGAP6	VGNC	VGNC:68123
Rattus norvegicus	ARHGAP6	RGD	RGD:2323364

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ARHGAP6 - Rho GTPase activating protein 6 Gene

关于 ARHGAP6

功能概要

ARHGAP6 基因产物(4)

ARHGAP6 蛋白结构

关联疾病

直系同源

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ARHGAP6 - Rho GTPase activating protein 6 Gene

关于 ARHGAP6

功能概要

ARHGAP6 基因产物(4)

ARHGAP6 蛋白结构

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z