2. Gene
  3. Spast - spastin Gene

Spast - spastin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Spg4; mKIAA1083

基因 ID: 50850 | 基因类型: protein coding

关于 Spast

功能概要

Predicted to enable microtubule-severing ATPase activity and tubulin binding activity. Involved in anterograde axonal transport and axonal transport of mitochondrion. Acts upstream of or within microtubule severing. Located in microtubule Cytoskeleton and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study hereditary spastic paraplegia 4. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 4. Orthologous to human SPAST (spastin). [provided by Alliance of Genome Resources, Apr 2022]

Spast 基因产物(4)

mRNA Protein Name
NM_001162870.2 NP_001156342.1 spastin isoform 1
NM_001357738.2 NP_001344667.1 spastin isoform 3
NM_001414036.1 NP_001400965.1 spastin isoform 4
NM_016962.3 NP_058658.2 spastin isoform 2
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in anterograde axonal transport IMP
IMP: 通过突变表型推断
19453301 MGI
involved in axonal transport of mitochondrion IMP
IMP: 通过突变表型推断
19453301 MGI
acts upstream of or within microtubule severing IDA
IDA: 通过直接分析推断
20530212 MGI
acts upstream of or within microtubule severing IGI
IGI: 通过遗传相互作用推断
20530212 MGI
acts upstream of or within microtubule severing IMP
IMP: 通过突变表型推断
20530212 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in microtubule cytoskeleton IDA
IDA: 通过直接分析推断
20530212 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12490534 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

spastin

spastic paraplegia 4 homolog

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13634 SPAST Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19038 Spast Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25527 Spast Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Spast NCBI NCBI:6683
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