PRKCSH - protein kinase C substrate 80K-H Gene

中文名称：蛋白激酶 C 底物 80K-H

种属: Homo sapiens

同用名: GIIB; PCLD; PLD1; G19P1; PCLD1; PKCSH; AGE-R2; VASAP-60

基因 ID: 5589 | 基因类型: protein coding

关于 PRKCSH

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:11,435,635-11,450,968 (from NCBI)

This gene has 22 transcripts (splice variants), 188 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 74.5), thyroid (RPKM 56.4) and 25 other tissues.

功能概要

该基因编码葡萄糖苷酶 II 的 β 亚基，葡萄糖苷酶 II 是内质网中的一种 N-连接聚糖加工酶。编码的蛋白质是一种酸性磷蛋白，已知是蛋白激酶 C 的底物。该基因的突变与常染色体显性多囊性肝病有关。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 1 月]

This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum. The encoded protein is an acidic phosphoprotein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

PRKCSH 基因产物(7)

mRNA	Protein	Name
NM_001001329.3	NP_001001329.1	glucosidase 2 subunit beta isoform 2 precursor
NM_001289102.2	NP_001276031.1	glucosidase 2 subunit beta isoform 2 precursor
NM_001289103.2	NP_001276032.1	glucosidase 2 subunit beta isoform 3 precursor
NM_001289104.2	NP_001276033.1	glucosidase 2 subunit beta isoform 3 precursor
NM_001379608.1	NP_001366537.1	glucosidase 2 subunit beta isoform 1 precursor
NM_001379609.1	NP_001366538.1	glucosidase 2 subunit beta isoform 2 precursor
NM_002743.3	NP_002734.2	glucosidase 2 subunit beta isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables phosphoprotein binding	IPI IPI: 通过物理相互作用推断	19801576	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10929008	GOA
enables protein kinase C binding	IPI IPI: 通过物理相互作用推断	15707389	GOA
enables transmembrane transporter binding	IPI IPI: 通过物理相互作用推断	19801576	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in N-glycan processing	IDA IDA: 通过直接分析推断	10929008	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	19801576	GOA
part of glucosidase II complex	IDA IDA: 通过直接分析推断	10929008	GOA
part of glucosidase II complex	IPI IPI: 通过物理相互作用推断	10929008	GOA
located in intracellular membrane-bounded organelle	IMP IMP: 通过突变表型推断	10929008	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRKCSH 蛋白结构

PRKCSH-like

EF-hand_5

PRKCSH_1

0
100
200
300
400
500
528 a.a.

蛋白主名

其他名称

glucosidase 2 subunit beta

AGE-binding receptor 2

PRKCSH 抗体

目录号	产品名	应用	反应物种
HY-P80405	Glucosidase 2 subunit beta Antibody (YA409)	WB, IHC-P, ICC/IF	Human

关联疾病

疾病名称

别名

Polycystic Liver Disease 1 With Or Without Kidney Cysts

Polycystic Liver Disease 1	PCLD1
Cyst	Liver Disease, Polycystic, Type 1
Polycystic Liver Disease

Polycystic Liver Disease

Autosomal Dominant Polycystic Liver Disease	Isolated Polycystic Liver Disease
Pcld	Congenital Cystic Liver Disease
Congenital Hepatic Cyst	Fibrocystic Liver Disease
Isolated Autosomal Dominant Polycystic Liver Disease	Adpcld
Liver Disease, Polycystic	Multiple Cysts Of Liver
Pld - [Polycystic Liver Disease]	Polycystic Liver Disorder
Polycystic Liver	Congenital Polycystic Disease Of Liver
Congenital Polycystic Liver Disease

Liver Disease

Liver Failure	Liver Diseases
Abnormality Of The Liver	Liver Dysfunction
Disorder Of Liver	Hepatic Disorder
Hepatic Disease	Disease Of Bilirubin Metabolism
Disorder Of Bilirubin Metabolism	Liver Decompensation
Liver Function Failure	Hepatic Failure Nos
Liver Failure Nos	End Stage Liver Disease
Decompensated Liver Failure	Decompensation Of Liver Function
Hepatic Decompensation	Hepatic Insufficiency
Liver Cell Necrosis With Hepatic Failure	Liver Insufficiency
Decompensated Liver Disease	End Stage Liver Failure
Liver Necrosis With Hepatic Failure

Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease

Autosomal Recessive Polycystic Kidney Disease	Arpkd
Polycystic Kidney Disease, Autosomal Recessive	Polycystic Kidney And Hepatic Disease 1
Pkhd1	PKD4
Polycystic Kidney Disease 4 With Or Without Hepatic Disease	Polycystic Kidney Disease, Infantile, Type I
Polycystic Kidney Disease, Infantile Type	Polycystic Kidney, Autosomal Recessive
Pkd3, Formerly	Polycystic Kidney Disease 4, With Or Without Hepatic Disease
Arpkd/Chf	Ar-Pkd
Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease	Infantile Polycystic Kidney Disease Type I
Pkd3	Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease
Polycystic Kidney Disease 3, Autosomal Dominant

Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 1	PKD1
Adpkd	Polycystic Kidney Disease, Adult, Type I
Apkd1	Potter Type Iii Polycystic Kidney Disease
Polycystic Kidney Disease, Adult	Potter Type Iii Polycystic Kidney Disease, Formerly
Polycystic Kidney Disease, Type 1	Adpkd1
Adult Polycystic Kidney Disease Type 1	Autosomal Dominant Polycystic Kidney Disease 1
Pkd-1	Polycystic Kidney Disease Adult
Polycystic Kidney Disease Type I	Polycystic Kidneys
Polycystic Kidney Disease, Adult Type I	Polycystic Kidney Type 1 Autosomal Dominant Disease
Kidney Disease, Polycystic, Type 1	Polycystic Kidney, Autosomal Dominant
Polycystic Kidney, Type 1 Autosomal Dominant Disease	Polycystic Kidney Diseases

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Caroli Disease

Caroli Disease Isolated	Congenital Polycystic Dilatation Of Intrahepatic Bile Ducts
Cystic Dilatation Of The Intrahepatic Biliary Tree	Caroli Syndrome
Carolis Disease

Polycystic Kidney Disease 3 With Or Without Polycystic Liver Disease

PKD3	Polycystic Kidney Disease, Adult, Type Iii
Apkd3	Polycystic Kidney Disease 3
Polycystic Kidney Disease, Type 3	Polycystic Kidney Disease 3 Without Polycystic Liver Disease
Polycystic Kidney Disease 3, Autosomal Dominant

Congenital Anomalies Of Kidney And Urinary Tract 1

CAKUT1	Renal Hypodysplasia, Nonsyndromic, 1
Rhdns1	Congenital Anomalies Of The Kidney And Urinary Tract 1
Non-Syndromic Renal Hypodysplasia 1	Kidney And Urinary Tract, Anomalies, Congenital, Susceptibility To, Type 1

Nephronophthisis-Like Nephropathy 1

NPHPL1

Nephronophthisis-Like Nephropathy, Type 1

Renal Dysplasia, Cystic

CYSRD	Renal Dysplasia, Cystic, Susceptibility To
Diffuse Cystic Renal Dysplasia	Renal Dysplasia Diffuse Cystic
Cystic Renal Dysplasia	Susceptibility To Cystic Renal Dysplasia
Dysplasia, Renal, Cystic, Susceptibility To	Multicystic Dysplastic Kidney

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type	Adpkd
Polycystic Kidney Diseases	Polycystic Kidney, Autosomal Dominant
Congenital Biliary Ectasias	Polycystic Kidney And Hepatic Disease 1
Polycystic Kidney Disease, Autosomal Dominant	Kidney, Polycystic, Disease, Autosomal Dominant
Adult Polycystic Kidney Disease	Polycystic Kidney, Adult Type
Apckd - [Autosomal Polycystic Kidney Disease]

Cystic Kidney Disease

Renal Cyst	Simple Renal Cyst
Kidney Cysts	Kidney Diseases, Cystic
Renal Cysts	Kidney Cyst
Cystic Kidney	Congenital Cystic Kidney Disease
Cystic Kidney Diseases	Bosniak 1 Cyst

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11140	PRKCSH Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	PRKCSH	VGNC	VGNC:76417
Canis familiaris	PRKCSH	VGNC	VGNC:44984
Felis catus	PRKCSH	VGNC	VGNC:69068
Bos taurus	PRKCSH	VGNC	VGNC:33335
Mus musculus	PRKCSH	MGD	MGI:107877
Rattus norvegicus	PRKCSH	RGD	RGD:1309628

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PRKCSH - protein kinase C substrate 80K-H Gene

关于 PRKCSH

功能概要

PRKCSH 基因产物(7)

PRKCSH 蛋白结构

PRKCSH 抗体

关联疾病

直系同源

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PRKCSH - protein kinase C substrate 80K-H Gene

关于 PRKCSH

功能概要

PRKCSH 基因产物(7)

PRKCSH 蛋白结构

PRKCSH 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z