2. Gene
  3. Htra1 - HtrA serine peptidase 1 Gene

Htra1 - HtrA serine peptidase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: L56; HTRA; Prss11; RSPP11

基因 ID: 56213 | 基因类型: protein coding

关于 Htra1

功能概要

Enables serine-type peptidase activity. Involved in proteolysis. Acts upstream of or within chorionic trophoblast cell differentiation; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and placenta development. Located in collagen-containing extracellular matrix. Is expressed in several structures, including brain; limb; reproductive system; sensory organ; and skin. Human ortholog(s) of this gene implicated in CADASIL (multiple); hypertension; and macular degeneration (multiple). Orthologous to human HTRA1 (HtrA serine peptidase 1). [provided by Alliance of Genome Resources, Apr 2022]

Htra1 基因产物(1)

mRNA Protein Name
NM_019564.3 NP_062510.2 serine protease HTRA1 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14973287 MGI
enables serine-type peptidase activity IDA
IDA: 通过直接分析推断
15206957 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within chorionic trophoblast cell differentiation IMP
IMP: 通过突变表型推断
25446274 MGI
acts upstream of or within negative regulation of BMP signaling pathway IDA
IDA: 通过直接分析推断
14973287 MGI
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
14973287 MGI
acts upstream of or within placenta development IMP
IMP: 通过突变表型推断
25446274 MGI
involved in proteolysis IDA
IDA: 通过直接分析推断
15206957 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

serine protease HTRA1

high-temperature requirement A serine peptidase 1

insulin-like growth factor binding protein 5 protease

protease, serine, 11 (Igf binding)

serine protease 11

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99629 Galegenimab Inhibitor 99.91% Phase 2
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-163690 HTRA1-IN-1 Inhibitor / 否
HY-RS06486 HTRA1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17551 Htra1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24010 Htra1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Htra1 NCBI NCBI:5654
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