1. Gene
  2. EBF4 - EBF family member 4 Gene

EBF4 - EBF family member 4 Gene

中文名称:EBF 家族成员 4

种属: Homo sapiens

同用名: COE4; OE-4; O/E-4

基因 ID: 57593 | 基因类型: protein coding

关于 EBF4

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:2,692,780-2,760,108 (from NCBI)

This gene has 7 transcripts (splice variants), 200 orthologues and 3 paralogues. Broad expression in prostate (RPKM 9.6), endometrium (RPKM 8.9) and 24 other tissues.

功能概要

EBF4 属于保守的 Olf/EBF 螺旋-环-螺旋转录因子家族,其成员在神经发育和 B 细胞成熟中发挥重要作用 (Wang 等人,2002 [PubMed 12139918]) 。[OMIM 提供, 2008 年 3 月]

EBF4 belongs to the conserved Olf/EBF family of helix-loop-helix transcription factors, members of which play important roles in neural development and B-cell maturation (Wang et al., 2002 [PubMed 12139918]).[supplied by OMIM, Mar 2008]

EBF4 基因产物(3)

mRNA Protein Name
NM_001110514.1 NP_001103984.1 transcription factor COE4 isoform 1
NM_001395167.1 NP_001382096.1 transcription factor COE4 isoform 2
NM_001395168.1 NP_001382097.1 transcription factor COE4 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
35939714 GOA
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
35939714 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
35939714 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
35939714 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T cell apoptotic process IMP
IMP: 通过突变表型推断
35939714 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
35939714 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
35939714 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

EBF4 蛋白结构

TIG

TIG: IPT/TIG domain (256 - 327)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 602 a.a.
蛋白主名 其他名称

transcription factor COE4

early B cell factor 4

直系同源

种属 基因名 来源 基因 ID
Canis familiaris EBF4 VGNC VGNC:40177
Rattus norvegicus EBF4 RGD RGD:1588215
Felis catus EBF4 VGNC VGNC:80090
Macaca mulatta EBF4 VGNC VGNC:71932
Mus musculus EBF4 MGD MGI:2385972
Bos taurus EBF4 VGNC VGNC:28298