1. Gene
  2. CARD18 - caspase recruitment domain family member 18 Gene

CARD18 - caspase recruitment domain family member 18 Gene

中文名称:胱天蛋白酶招募域家族成员 18

种属: Homo sapiens

同用名: ICEBERG; UNQ5804; pseudo-ICE

基因 ID: 59082 | 基因类型: protein coding

关于 CARD18

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:105,137,714-105,139,769 (from NCBI)

This gene has 5 transcripts (splice variants), 451 orthologues and 16 paralogues. Biased expression in skin (RPKM 6.9) and esophagus (RPKM 0.8).

功能概要

启用 CARD 域绑定活动和 Caspase 绑定活动。参与抑制半胱氨酸型内肽酶活性;白细胞介素 1 β 产生的负调节;和蛋白质结合活性的负调节。部分含蛋白质复合物。 [由基因组资源联盟提供,2022 年 4 月]

Enables CARD domain binding activity and Caspase binding activity. Involved in inhibition of cysteine-type endopeptidase activity; negative regulation of interleukin-1 beta production; and negative regulation of protein binding activity. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

CARD18 基因产物(1)

mRNA Protein Name
NM_021571.4 NP_067546.1 caspase recruitment domain-containing protein 18
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables CARD domain binding IPI
IPI: 通过物理相互作用推断
11821383 GOA
enables caspase binding IPI
IPI: 通过物理相互作用推断
11536016 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11536016 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in inhibition of cysteine-type endopeptidase activity IDA
IDA: 通过直接分析推断
11821383 GOA
involved in negative regulation of interleukin-1 beta production IDA
IDA: 通过直接分析推断
11536016 GOA
involved in negative regulation of protein binding IDA
IDA: 通过直接分析推断
11536016 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of protein-containing complex IDA
IDA: 通过直接分析推断
11536016 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CARD18 蛋白结构

CARD

CARD: Caspase recruitment domain (4 - 89)

  • 0
  • 90 a.a.
蛋白主名 其他名称

caspase recruitment domain-containing protein 18

ICEBERG caspase-1 inhibitor

关联疾病

疾病名称 别名
Asbestos-Related Lung Carcinoma
Colon Sarcoma

Colonic Sarcoma

Alveolar Periostitis

Dry Socket

Alveolitis Of Jaw

Dry Tooth Socket

Alveolar Pyorrhea

Alveolar Osteitis

Alveolitis Sicca Dolorosa

Alveolodental Periostitis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma