RPL26 - ribosomal protein L26 Gene

中文名称：核糖体蛋白 L26

种属: Homo sapiens

同用名: L26; DBA11

基因 ID: 6154 | 基因类型: protein coding

关于 RPL26

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,377,516-8,383,193 (from NCBI)

This gene has 13 transcripts (splice variants), 218 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in ovary (RPKM 654.6), bone marrow (RPKM 461.4) and 25 other tissues.

功能概要

核糖体是催化蛋白质合成的细胞器，由一个小的 40S 亚基和一个大的 60S 亚基组成。这些亚基一起由 4 种 RNA 和大约 80 种结构不同的蛋白质组成。该基因编码的核糖体蛋白是 60S 亚基的一个组成部分。该蛋白属于核糖体蛋白 L24P 家族。它位于细胞质中。作为典型的编码核糖体蛋白的基因，该基因有多个经过处理的假基因分散在基因组中。该基因的突变会导致 Diamond-Blackfan 贫血。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 10 月]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

RPL26 基因产物(3)

mRNA	Protein	Name
NM_000987.5	NP_000978.1	60S ribosomal protein L26
NM_001315530.2	NP_001302459.1	60S ribosomal protein L26
NM_001315531.2	NP_001302460.1	60S ribosomal protein L26

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables mRNA 5'-UTR binding	IMP IMP: 通过突变表型推断	16213212	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16213212	GOA
enables structural constituent of ribosome	IDA IDA: 通过直接分析推断	23636399	GOA
enables structural constituent of ribosome	IMP IMP: 通过突变表型推断	18697920	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IMP IMP: 通过突变表型推断	16213212	GOA
involved in cellular response to UV	IMP IMP: 通过突变表型推断	16213212	GOA
involved in cellular response to gamma radiation	IDA IDA: 通过直接分析推断	16213212	GOA
involved in positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IMP IMP: 通过突变表型推断	16213212	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP IMP: 通过突变表型推断	16213212	GOA
involved in positive regulation of translation	IMP IMP: 通过突变表型推断	16213212	GOA
involved in rRNA processing	IMP IMP: 通过突变表型推断	18697920	GOA
involved in regulation of translation involved in cellular response to UV	IMP IMP: 通过突变表型推断	16213212	GOA
involved in ribosomal large subunit biogenesis	IMP IMP: 通过突变表型推断	18697920	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	16213212	GOA
part of cytosolic large ribosomal subunit	IDA IDA: 通过直接分析推断	32669547	GOA
located in cytosolic ribosome	IDA IDA: 通过直接分析推断	16213212	GOA
located in nucleolus	IDA IDA: 通过直接分析推断	16213212	GOA
located in nucleoplasm	IDA IDA: 通过直接分析推断	16213212	GOA
part of ribonucleoprotein complex	IMP IMP: 通过突变表型推断	16213212	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPL26 蛋白结构

KOW

0
100
145 a.a.

蛋白主名

其他名称

60S ribosomal protein L26

large ribosomal subunit protein uL24

关联疾病

疾病名称

别名

Diamond-Blackfan Anemia 11

DBA11	Rpl26-Related Diamond-Blackfan Anemia
Anemia, Diamond-Blackfan, Type 11

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Macrocytic Anemia

Anemia Macrocytic	Anemia, Macrocytic
Macrocytic Anaemia

Pierre Robin Syndrome

Pierre Robin Sequence	Glossoptosis, Micrognathia, And Cleft Palate
Pierre Robin Syndrome Skeletal Dysplasia Polydactyly	Pierre-Robin Syndrome
Isolated Pierre Robin Sequence	Isolated Pierre-Robin Syndrome
PRBNS	Robin Sequence
Robin Syndrome	Isolated Pierre Robin Syndrome

Shwachman-Diamond Syndrome 1

Shwachman-Diamond Syndrome	Shwachman Syndrome
Shwachman-Bodian-Diamond Syndrome	Sds
Pancreatic Insufficiency And Bone Marrow Dysfunction	Shwachman-Bodian Syndrome
SDS1	Lipomatosis Of Pancreas, Congenital
Congenital Lipomatosis Of Pancreas	Shwachman-Diamond Type Metaphyseal Dysplasia
Metaphyseal Chondrodysplasia, Shwachman Type	Shwachman-Diamond-Oski Syndrome

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant	Dc
Dkc	Zinsser-Engman-Cole Syndrome
Dyskeratosis Congenita, Autosomal Dominant	Autosomal Dominant Dyskeratosis Congenita
Dkca	Dyskeratosis Congenita Scoggins Type
Zinsser-Cole-Engman Syndrome	X-Linked Dyskeratosis Congenita
Hoyeraal-Hreidarsson Syndrome

Aplastic Anemia

Aplastic Anemia, Susceptibility To	Anemia Aplastic
Idiopathic Aplastic Anemia	Secondary Aplastic Anemia
Idiopathic Bone Marrow Failure	Aplastic Anemia Idiopathic
AA	Anemia, Aplastic
Aplastic Anemia, Idiopathic	Erythroid Aplasia
Aa - [Aplastic Anaemia]	Haematopoietic Aplasia
Aleukia Haemorrhagica	Anaemia Due To Decreased Red Cell Production
Aplasia Bone Marrow	Aplastic Bone Marrow
Hypoplastic Anaemia Nos	Myeloid Bone Marrow Aplasia
Pancytopenia	Panhaematopenia
Hypoproliferative Anaemia	Medullary Hypoplasia
Red Blood Cells Hypoplastic Anaemia	Panmyelophthisis
Panhemocytopenia	Refractive Hypoproliferative Anaemia
Toxic Anaemia	Toxic Aplastic Anaemia
Aplastic Anaemia Due To Toxic Cause	Idiopathic Aplastic Anaemia Nos

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12178	RPL26 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS12179	RPL26L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS22784	Rpl26 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS29298	Rpl26 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	RPL26	MGD	MGI:106022
Rattus norvegicus	RPL26	RGD	RGD:1310607

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RPL26 - ribosomal protein L26 Gene

关于 RPL26

功能概要

RPL26 基因产物(3)

RPL26 蛋白结构

关联疾病

直系同源

热门区域

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RPL26 - ribosomal protein L26 Gene

关于 RPL26

功能概要

RPL26 基因产物(3)

RPL26 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z