SCTR - secretin receptor Gene

中文名称：分泌素受体

种属: Homo sapiens

同用名: SR

基因 ID: 6344 | 基因类型: protein coding

关于 SCTR

Cytogenetic location: 2q14.2 Genomic coordinates (GRCh38): 2:119,439,843-119,524,483 (from NCBI)

This gene has 5 transcripts (splice variants), 130 orthologues and 42 paralogues. Biased expression in duodenum (RPKM 6.3), pancreas (RPKM 4.3) and 5 other tissues.

功能概要

该基因编码的蛋白质是 G 蛋白偶联受体，属于胰高血糖素-VIP-分泌素受体家族。它结合促胰液素，促胰液素是胰腺碳酸氢盐、电解质和容量分泌最有效的调节剂。胰泌素及其受体被认为与胰腺癌和自闭症有关。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic Cancer and autism. [provided by RefSeq, Jul 2008]

SCTR 基因产物(13)

mRNA	Protein	Name
NM_002980.3	NP_002971.2	secretin receptor precursor
XM_011511621.3	XP_011509923.1	secretin receptor isoform X3
XR_007079571.1
XR_922984.3
XM_047445399.1	XP_047301355.1	secretin receptor isoform X1
XM_047445403.1	XP_047301359.1	secretin receptor isoform X7
XM_047445402.1	XP_047301358.1	secretin receptor isoform X6
XR_001738888.2
XR_001738889.2
XM_047445401.1	XP_047301357.1	secretin receptor isoform X5
XM_047445400.1	XP_047301356.1	secretin receptor isoform X2
XM_047445404.1	XP_047301360.1	secretin receptor isoform X8
XM_017004670.2	XP_016860159.2	secretin receptor isoform X4

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables peptide hormone binding	IPI IPI: 通过物理相互作用推断	7612008	GOA
enables secretin receptor activity	IDA IDA: 通过直接分析推断	7612008	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	7612008	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasmic microtubule	IDA IDA: 通过直接分析推断	23264731	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SCTR 蛋白结构

HRM

7tm_2

0
100
200
300
400
440 a.a.

蛋白主名

其他名称

secretin receptor

pancreatic secretin receptor

关联疾病

疾病名称

别名

Isolated Growth Hormone Deficiency, Type Ib

Isolated Growth Hormone Deficiency Type Ib	IGHD1B
Ighd Ib	Growth Hormone Deficiency, Isolated, Type Ib
Congenital Ighd Type Ib	Congenital Isolated Gh Deficiency Type Ib
Congenital Isolated Growth Hormone Deficiency Type Ib	Dwarfism Of Sindh
Pituitary Dwarfism I	Isolated Growth Hormone Deficiency Type 1b
Ighd 1b	Growth Hormone Deficiency, Isolated, 1b

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Retinitis Pigmentosa 18

RP18	Retinitis Pigmentosa-18
Retinitis Pigmentosa, Type 18

Pancreas Disease

Abnormality Of The Pancreas

Pancreatic Diseases

X-Linked Nephrogenic Diabetes Insipidus

Nephrogenic Diabetes Insipidus Type 1

Doid:0081060

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Gastrinoma

Gastrin Cell Tumour	Gastrin Secreting Tumor
Malignant Gastrinoma	Gastrinoma, Malignant

Metaphyseal Chondrodysplasia, Jansen Type

Metaphyseal Chondrodysplasia, Murk Jansen Type	MCDJ
Jansen'S Metaphyseal Chondrodysplasia	Murk Jansen Type Metaphyseal Chondrodysplasia
Jansen Type Metaphyseal Chondrodysplasia	Jansen Disease
Jansen Metaphyseal Chondrodysplasia	Jansen Metaphyseal Dysostosis
Metaphyseal Chondrodysplasia Murk Jansen Type	Chondrodysplasia, Metaphyseal, Murk Jansen Type

Polycystic Liver Disease

Autosomal Dominant Polycystic Liver Disease	Isolated Polycystic Liver Disease
Pcld	Congenital Cystic Liver Disease
Congenital Hepatic Cyst	Fibrocystic Liver Disease
Isolated Autosomal Dominant Polycystic Liver Disease	Adpcld
Liver Disease, Polycystic	Multiple Cysts Of Liver
Pld - [Polycystic Liver Disease]	Polycystic Liver Disorder
Polycystic Liver	Congenital Polycystic Disease Of Liver
Congenital Polycystic Liver Disease

Suppurative Cholangitis

Pancreatic Cancer

Pancreatic Carcinoma	Familial Pancreatic Carcinoma
Pancreatic Neoplasm	Carcinoma Of Pancreas
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Pancreatic Carcinoma, Somatic	Pancreatic Cancer, Somatic
Ca Body Of Pancreas	Ca Head Of Pancreas
Ca Tail Of Pancreas	Malignant Neoplasm Of Body Of Pancreas
Malignant Neoplasm Of Head Of Pancreas	Malignant Neoplasm Of Tail Of Pancreas
Pancreas Neoplasm	Exocrine Cancer
Exocrine Pancreas Carcinoma	Hereditary Pancreatic Cancer
Hereditary Pancreatic Carcinoma	PNCA
Cancer Of The Pancreas	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Jejunal Somatostatinoma

Jejunal Delta Cell Somatostatin Producing Tumor	Somatosatinoma Of Jejunum
Jejunal Somatostatin-Producing Neuroendocrine Tumor

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis	PSC
Sclerosing Cholangitis	Cholangitis, Sclerosing
Cholangitis Primary Sclerosing	Psc - [Primary Sclerosing Cholangitis]

Chondrodysplasia, Blomstrand Type

Chondrodysplasia Blomstrand Type	BOCD
Blomstrand Lethal Chondrodysplasia	Blomstrand Lethal Osteochondrodysplasia
Blomstrand'S Lethal Chondrodysplasia	Blc
Blomstrand Chondrodysplasia	Blomstrand Osteochondrodysplasia

Esophageal Adenosquamous Carcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12568	SCTR Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS12569	Sctr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS12570	Sctr Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	SCTR	VGNC	VGNC:34370
Macaca mulatta	SCTR	VGNC	VGNC:76996
Felis catus	SCTR	VGNC	VGNC:64937
Mus musculus	SCTR	MGD	MGI:2441720
Rattus norvegicus	SCTR	RGD	RGD:621342
Canis familiaris	SCTR	VGNC	VGNC:45934

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SCTR - secretin receptor Gene

关于 SCTR

功能概要

SCTR 基因产物(13)

SCTR 蛋白结构

关联疾病

直系同源

热门区域

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SCTR - secretin receptor Gene

关于 SCTR

功能概要

SCTR 基因产物(13)

SCTR 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z