2. Immunology/Inflammation
  3. CTLA-4
  4. Anti-Mouse CTLA-4 Antibody (9H10)

Anti-Mouse CTLA-4 Antibody (9H10) 

目录号: HY-P990789 纯度: 95.00%
COA 技术支持

Anti-Mouse CTLA-4 Antibody (9H10) 是一种叙利亚仓鼠 IgG 抗体抑制剂，靶向 CTLA-4。Anti-Mouse CTLA-4 Antibody (9H10) 可结合小鼠 CTLA-4，并阻断 CTLA-4 与其配体之间的相互作用。Anti-Mouse CTLA-4 Antibody (9H10) 在多种肿瘤模型中显示出强大的抗肿瘤作用，如乳腺癌和结肠癌。

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Anti-Mouse CTLA-4 Antibody (9H10)

Anti-Mouse CTLA-4 Antibody (9H10) Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥1350
In-stock
5 mg ￥4050
In-stock
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100 mg   询价  

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Anti-Mouse CTLA-4 Antibody (9H10) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CTLA-4 Antibody (9H10) is a kind of syrian hamster IgG antibody inhibitor, targeting to CTLA-4. Anti-Mouse CTLA-4 Antibody (9H10) binds mouse CTLA-4 and blocks the interaction between CTLA-4 and its ligand. Anti-Mouse CTLA-4 Antibody (9H10) shows potent anti-tumor effect in various tumor models, such as breast and colon cancer[1][2][3][4].

同型

Syrian hamster IgG
反应种属

Mouse
IC50 & Target

CTLA-4
体内研究
(In Vivo)

Anti-Mouse CTLA-4 Antibody (9H10) (200 μg，腹腔注射，在第 15、18、21 天给药) 与放疗联合使用可抑制 4T1 肿瘤模型小鼠中的肿瘤生长和转移[1]。
Anti-Mouse CTLA-4 Antibody (9H10) (200 μg，腹腔注射，在第 1、4、7 天给药) 与放疗联合使用可抑制 4T1 肿瘤模型小鼠中的肿瘤生长并延长生存期[2]。
Anti-Mouse CTLA-4 Antibody (9H10) (200 μg，腹腔注射，在第 14、17、20 天给药) 与放疗联合使用可抑制乳腺癌和结肠癌模型小鼠中原发性和继发性肿瘤的生长[3]。
Anti-Mouse CTLA-4 Antibody (9H10) (首次 100 μg，随后 3 天给一次 50 μg，共两次，腹腔注射) 可提高星形胶质瘤模型小鼠的长期生存率，且未出现实验性自身免疫性脑脊髓炎[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4T1 tumor mice models[1]
Dosage: 200 μg
Administration: Intraperitoneally injection, at day 15, 18, 21, companied with radiation
Result: Inhibited tumors and their metastases.
Reduced CFP+ 4T1 cells.
Demonstrated persistence of highly active immune effector cells.
Reversed migratory and motilityactivity elicited by each monotherapy.
Animal Model: 4T1tumor mice models[2]
Dosage: 200 μg
Administration: Intraperitoneally injection, at day 1, 4, 7, companied with radiation
Result: Significantly delayed the growth of the primary irradiated tumor and prolonged survival of mice.
Animal Model: TSA breast/MCA38 colon cancer mice models[3]
Dosage: 200 μg
Administration: Intraperitoneally injection, at day 14, 17, 20, companied with radiation
Result: Inhibited primary and secondary tumor growth.
Increased tumor-infiltrating lymphocytes.
Animal Model: SMA-560 astrocytoma mice models[4]
Dosage: 100 μg for the first time and then two 50 μg-doses at 3-day intervals
Administration: Intraperitoneally injection
Result: Elicited long-term survival in 80% of mice and no experimental allergic encephalomyelitis.
Restored CD4 numbers in all locations and Treg cells.
Reestablished a normal CD4proliferative capacity.
Enhanced proliferation and Treg resistance on CD4+CD25- T cells but does not alter Treg suppressive function.
基因 ID

12477  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse CTLA-4 Antibody (9H10) 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CTLA-4 Antibody (9H10)CTLA-4Cytotoxic T-lymphocyte-associated protein 4CD152Breast cancerColon cancer4T1AstrocytomaRadiationInhibitorinhibitorinhibit

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