2. Immunology/Inflammation
  3. CTLA-4
  4. Anti-Mouse CTLA-4 Antibody (9D9)

Anti-Mouse CTLA-4 Antibody (9D9) 

目录号: HY-P99132 纯度: 95.00%
COA 技术支持

Anti-Mouse CTLA-4 Antibody (9D9) 是一种抗小鼠 CTLA-4 IgG2b 的单克隆抗体。Anti-Mouse CTLA-4 Antibody (9D9) 可以结合 CTLA-4 并阻断其与 B7 的结合。Anti-Mouse CTLA-4 Antibody (9D9) 通过调节 CD8+ T 细胞与调节性 T 细胞 (Tregs) 的比例来增强 T 细胞功能。Anti-Mouse CTLA-4 Antibody (9D9) 可用于研究癌症如结肠癌和黑色素瘤。

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规格 价格 是否有货 数量
1 mg ￥1700
In-stock
5 mg ￥6200
In-stock
10 mg   询价  
50 mg   询价  

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Anti-Mouse CTLA-4 Antibody (9D9) 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CTLA-4 Antibody (9D9) is an anti-mouse CTLA-4 IgG2b monoclonal antibody. Anti-Mouse CTLA-4 Antibody (9D9) can bind to CTLA-4 and block its binding to B7. Anti-Mouse CTLA-4 Antibody (9D9) enhances T cell function by regulating the ratio of CD8+ T cells to regulatory T cells (Tregs). Anti-Mouse CTLA-4 Antibody (9D9) can be used for research on cancer such as colon cancer and melanoma[1][2].

同型

Mouse IgG2b kappa
推荐同型对照抗体
IC50 & Target

CTLA-4
体外研究
(In Vitro)

Anti-Mouse CTLA-4 Antibody (9D9) (0.1-1000 nM, 2 小时) 在 HEK293-F 细胞中与 CTLA-4WT (KD = 15.4 nM) 和 CTLA-4del36 (KD = 69.6 nM) 具有高结合度[1]。
Anti-Mouse CTLA-4 Antibody (9D9) (0.01-1000 nM, 1 小时) 显著阻断 HEK293-F 细胞中 B7 与 CTLA-4 的结合 (ELISA 的 IC50 = 23.5 nM, 细胞表面 IC50 = 24.4 nM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CTLA-4 Antibody (9D9) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse CTLA-4 Antibody (9D9) (200 μg, 腹腔注射或瘤内注射, 在第 7, 10 和 14 天) 在携带 MC38 肿瘤的雌性 C57BL/6 小鼠体内具有显著的抗肿瘤活性，并增加 CD4+/CD8+ T 细胞活化[1]。
Anti-Mouse CTLA-4 Antibody (9D9) (100 μg/剂, 在第 3, 6 和 9 天腹腔注射) 在携带 B16-F10 肿瘤的雄性 C57BL/6 小鼠体内具有显著的抗肿瘤活性并延长存活时间[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 1 M MC38 cells injected female C57BL/6 mice (6-8 weeks)[1]
Dosage: 200 μg
Administration: Intraperitoneal injection (i.p.) or intratumoral injection (i.t.), on day 7, 10 and 14
Result: Achieved a cure rate of 47 % (i.t.) or 33 % (i.p.).
Exhausted intratumoral Tregs and activates lymph node T cells.
Animal Model: 2.5×104 B16-F10 cells injected male C57BL/6 mice (6 weeks)[2]
Dosage: 100 μg/dose, combinated with MGN1703
Administration: Intraperitoneal injection (i.p.), on day 3, 6 and 9
Result: Cured 50% of mice and prolongs survival time.
基因 ID

12477  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized CTLA-4 Protein, Mouse (HEK293, His, HY-P71991) can bind Anti-Mouse CTLA-4 Antibody (9D9). The EC50 for this effect is 1.979 ng/mL.
纯度 & 产品资料

纯度: ≥98.0%

COA (266 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse CTLA-4 Antibody (9D9) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CTLA-4 Antibody (9D9)CTLA-4Cytotoxic T-lymphocyte-associated protein 4CD152colon cancermelanomaTregsInhibitorinhibitorinhibit

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目录号：
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