2. Immunology/Inflammation
  3. CTLA-4
  4. Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9)

Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) 

目录号: HY-P990256 纯度: 95.00%
COA 技术支持

Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) 是一种源自小鼠的 IgG2a κ 型抗体抑制剂，靶向小鼠 CTLA-4/CD152。Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) 的 Fc 片段含有 LALA-PG 突变，使其无法结合内源性 Fcγ 受体。Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) 可用于癌症和免疫学研究，如结肠癌。

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Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9)

Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥2200
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Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) is a mouse-derived IgG2a κ type antibody inhibitor targeting to mouse CTLA-4/CD152. Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) contains a LALA-PG mutation in the Fc fragment rendering it unable to bind to endogenous Fcγ receptors. Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) can be used for the researches of cancer and immunology, such as colon[1][2].

同型

Mouse IgG2a (LALA-PG)
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

CTLA-4/CD152
体外研究
(In Vitro)

抗体框架具有稳定性、特异性和适应性，同时具有结合抗原和内源免疫受体。 单克隆抗体具有几种衍生物，包括双特异性抗体、抗体-药物缀合物和抗体片段，在免疫学和肿瘤学等领域具有显著效果。 设计抑制性抗体时，需要注意包括抗原特异性可变区的鉴定、表达系统的选择、多特异性形式的使用以及基于片段化、寡聚化或与其他功能部分缀合的抗体衍生物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) (注射前 1 天 500 μg，第 2 天和第 5 天 250 μg，腹腔注射) 可增加 NP-2W1S-GFP 移植小鼠的调节性 T 细胞、T 滤泡辅助细胞和 T 滤泡调节细胞[1]。
Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) (15 mg/kg，腹腔注射，单剂量) 在 colon 26 结肠肿瘤模型小鼠中显示出强大的抗肿瘤作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human CD2 IL-4 reporter C57BL/6 mice were injected NP-2W1S-GFP in alum[1]
Dosage: 500 μg at 1 day before injection, 250 μg at day 2 and 5
Administration: Intraperitoneally injection
Result: Caused the expansion of total regulatory T cells, T follicular helper and T follicular regulatory cells.
Induced significant expansion of tetramer-binding PD1+Bcl6+ Tfh, PD1+Bcl6- activated T cells and PD1-Bcl6- cells.
Decreased numbers of tetramer-binding T follicular regulatory cells.
Animal Model: Colon 26 tumor mice models[2]
Dosage: 15 mg/kg
Administration: Intraperitoneally injection, a single dose
Result: Showed tumor regressions in 100% of animals.
Resulted in depletion of tumor-associated T cells and a shift in the ratio of CD8+ to regulatory T cells cells.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (267 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9)CTLA-4Cytotoxic T-lymphocyte-associated protein 4CD152CancerImmunologyColonRegulatory T cellsInhibitorinhibitorinhibit

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