SOX12 - SRY-box transcription factor 12 Gene

中文名称：SRY-box 转录因子 12

种属: Homo sapiens

同用名: SOX22

关于 SOX12

功能概要

SOX 转录因子家族成员的特征是存在一个 DNA 结合高迁移率基团 (HMG) 结构域，与性别决定区 Y (SRY) 的 HMG 盒同源。作为 HMG 结构域超家族的一个亚组，SOX 蛋白与多种发育过程中的细胞命运决定有关。 SOX 转录因子在早期发育过程中具有多种组织特异性表达模式，并已被提议用作靶标特异性转录因子和/或染色质结构调控元件。由该基因编码的蛋白质基于保守结构域被鉴定为 SOX 家族成员，其在各种组织中的表达表明在多种细胞类型的分化和维持中发挥作用。[RefSeq 提供，2013 年 1 月]

Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains, and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types. [provided by RefSeq, Jan 2013]