RO60 - Ro60, Y RNA binding protein Gene

中文名称：Ro60, Y RNA 结合蛋白

种属: Homo sapiens

同用名: SSA2; RORNP; TROVE2

基因 ID: 6738 | 基因类型: protein coding

关于 RO60

Cytogenetic location: 1q31.2 Genomic coordinates (GRCh38): 1:193,059,612-193,091,777 (from NCBI)

This gene has 12 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in brain (RPKM 6.6), prostate (RPKM 5.8) and 25 other tissues.

功能概要

启用 RNA 结合活性。参与细胞对干扰素-α 的反应和基因表达的调节。位于细胞质和核质中。核糖核蛋白复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA binding activity. Involved in cellular response to interferon-alpha and regulation of gene expression. Located in cytosol and nucleoplasm. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]

RO60 基因产物(6)

mRNA	Protein	Name
NM_001042369.2	NP_001035828.1	RNA-binding protein RO60 isoform 1
NM_001042370.2	NP_001035829.2	RNA-binding protein RO60 isoform 3
NM_001173524.2	NP_001166995.1	RNA-binding protein RO60 isoform 2
NM_001173525.1	NP_001166996.1	RNA-binding protein RO60 isoform 4
NM_001331020.2	NP_001317949.1	RNA-binding protein RO60 isoform 5
NM_004600.5	NP_004591.2	RNA-binding protein RO60 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA binding	IDA IDA: 通过直接分析推断	26382853	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to interferon-alpha	IDA IDA: 通过直接分析推断	26382853	GOA
involved in regulation of gene expression	IDA IDA: 通过直接分析推断	26382853	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of ribonucleoprotein complex	IDA IDA: 通过直接分析推断	17289661	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RO60 蛋白结构

TROVE

DUF2201

0
100
200
300
400
500
538 a.a.

蛋白主名

其他名称

RNA-binding protein RO60

60 kDa ribonucleoprotein Ro

关联疾病

疾病名称

别名

Sjogren Syndrome

Sicca Syndrome	Sjogren'S Syndrome
Sjögren Syndrome	Sjogren-Gougerot Syndrome
Keratoconjunctivitis Sicca	Sjögren'S Syndrome
Xerodermosteosis	Dacryosialoadenopathia Atrophicans
Gougerot-Houwer-Sjogren Syndrome	Gougerot-Sjogren Syndrome
Keratoconjunctivitis Sicca-Xerostomia	Secreto-Inhibitor-Xerodermostenosis
Primary Sjogren Syndrome	Primary Sjogren-Gougerot Syndrome
Sjogrens Syndrome Primary	Sjogrens Syndrome
Dry Eye Syndromes

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Heart Block, Congenital

Congenital Heart Block	Heart Block Congenital
Congenital Atrioventricular Block

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Xerophthalmia

Conjunctival Xerosis

Systemic Scleroderma

Scleroderma	Progressive Systemic Sclerosis
Systemic Sclerosis	Scleroderma, Systemic
Scleroderma Syndrome	Dermatosclerosis
Familial Progressive Scleroderma	Progressive Scleroderma
Scleroderma Disease	Scleroderma, Localized
Diffuse Scleroderma	Scleroderma, Familial Progressive

Autoimmune Disease Of Exocrine System

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome	Chromosome 11p11.2 Deletion Syndrome
Pss	11p11.2 Deletion
P11pds	Defect11 Syndrome
Deletion Of Chromosome 11p11.2	POSHS

Second-Degree Atrioventricular Block

Second-Degree Heart Block	Second Degree Atrioventricular Block
Second Degree Atrioventricular Heart Block	Second Degree Heart Block
Incomplete Atrioventricular Block, Second Degree Nos	Second-Degree Block, Type 1 And 2
Atrioventricular Block, Type 1 And 2	Second Degree Incomplete Atrioventricular Block
Av - [Atrioventricular] Block 2nd

Endocardial Fibroelastosis

Endomyocardial Fibroelastosis	Elastomyofibrosis
EFE	Efe - [Endocardial Fibroelastosis]
Primary Endocardial Fibroelastosis	Fibroelastosis Cordis
Fetal Endocarditis	Fibroelastosis
Congenital Endocardial Fibroelastosis	Congenital Valvular Endocarditis

Libman-Sacks Endocarditis

Libmann-Sachs, Endocarditis In Systemic Lupus Erythematosus

Keratoconjunctivitis Sicca

Kcs	Dry Eye Syndromes
Keratitis Sicca	Xerophthalmia

Antisynthetase Syndrome

As Syndrome

Anti-Jo1 Syndrome

Cutaneous Lupus Erythematosus

Lupus Erythematosus, Cutaneous

Lupus Erythematosus Cutaneous

Atrioventricular Block

Av Block

Neonatal Myasthenia Gravis

Myasthenia Gravis, Neonatal

Lacrimal Apparatus Disease

Lacrimal Apparatus Diseases

Sialadenitis

Sialoadenitis	Adenitis, Salivary Gland
Salivary Gland Inflammation	Salivary Gland Adenitis
Sialitis	Inflammation Of Salivary Gland
Inflammation Of Salivary Duct Or Gland	Salivary Glandular Adenitis
Sialoangiitis	Sialoangitis
Sialodochitis

Dry Eye Syndrome

Dry Eye Syndromes	Dry Eye Disease
Tear Film Insufficiency	Xerophthalmia

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Childhood Type Dermatomyositis

Juvenile Dermatomyositis	Juvenile Dm
Childhood Dermatomyositis	Amyopathic Dermatomyositis
Adm	Dermatomyositis Sine Myositis
Dermatomyositis, Childhood Type

Chromosomal Deletion Syndrome

Limited Scleroderma

Limited Cutaneous Systemic Sclerosis	Limited Systemic Sclerosis
Systemic Sclerosis Sine Scleroderma	Crest Syndrome
Limited Cutaneous Systemic Scleroderma	Scleroderma, Limited
Systemic Sclerosis, Limited	Progressive Systemic Sclerosis Sine Scleroderma
Scleroderma, Sine	Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome
Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-123838	Ro60-0175	Agonist	99.52%	否
HY-103140	Ro60-0175 fumarate	Agonist	99.47%	否
HY-RS12109	RO60 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	RO60	VGNC	VGNC:36379
Rattus norvegicus	RO60	RGD	RGD:1305083
Macaca mulatta	RO60	VGNC	VGNC:100063
Mus musculus	RO60	MGD	MGI:106652
Felis catus	RO60	VGNC	VGNC:64713
Canis familiaris	RO60	VGNC	VGNC:47864
Others	RO60	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RO60 - Ro60, Y RNA binding protein Gene

关于 RO60

功能概要

RO60 基因产物(6)

RO60 蛋白结构

关联疾病

直系同源

热门区域

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RO60 - Ro60, Y RNA binding protein Gene

关于 RO60

功能概要

RO60 基因产物(6)

RO60 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z