2. Gene
  3. XCL2 - X-C motif chemokine ligand 2 Gene

XCL2 - X-C motif chemokine ligand 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：XC 基序趋化因子配体 2

种属: Homo sapiens

同用名: SCM1B; SCYC2; SCM-1b

基因 ID: 6846 | 基因类型: protein coding

关于 XCL2

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:168,540,768-168,543,997 (from NCBI)

This gene has 1 transcript (splice variant), 117 orthologues and 25 paralogues. Broad expression in spleen (RPKM 4.0), bone marrow (RPKM 3.8) and 18 other tissues.

功能概要

预测可启用 CCR 趋化因子受体结合活性和趋化因子活性。预计参与多个过程，包括细胞对细胞因子刺激的反应；白细胞趋化性；和 T 细胞趋化性的正调节。预测位于细胞外区域。预计在细胞外空间活跃。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable CCR Chemokine Receptor binding activity and chemokine activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of T cell chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

XCL2 基因产物(1)

mRNA Protein Name
NM_003175.4 NP_003166.1 cytokine SCM-1 beta precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

XCL2 蛋白结构

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (31 - 83)

  • 0
  • 100
  • 114 a.a.
蛋白主名 其他名称

cytokine SCM-1 beta

XC chemokine ligand 2

XCL2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
XCL2 Q9UBD3 KRTAP10-9 Homo sapiens P60411
Validated Y2H
25416956
种属内
XCL2 Q9UBD3 KRTAP10-9 Homo sapiens P60411
Y2H Array
25416956
种属内
XCL2 Q9UBD3 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
25416956
种属内
XCL2 Q9UBD3 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
种属内
XCL2 Q9UBD3 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
种属内
XCL2 Q9UBD3 CCL5 Homo sapiens P13501
SPR
28381538
种属内
XCL2 Q9UBD3 CXCL12 Homo sapiens P48061
SPR
28381538
种属内
XCL2 Q9UBD3 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
种属内
XCL2 Q9UBD3 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
种属内
XCL2 Q9UBD3 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 XCL2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74461 XCL2/SCM-1 beta Protein, Human (sf9, His) Q9UBD3 (M1-G114) ≥95%

关联疾病

疾病名称 别名
Recombinase Activating Gene 1 Deficiency
Combined Cellular And Humoral Immune Defects With Granulomas

Combined Immunodeficiency With Skin Granulomas

CCHIDG

Cid Due To Rag 1/2 Deficiency

Combined Immunodeficiency Due To Rag 1/2 Deficiency

Combined Immunodeficiency With Granulomatosis

CHIDG

Immune Defects, Combined Cellular And Humoral With Granulomas
Photokeratitis
Immunodeficiency 44

IMD44
Cataract 44

CTRCT44

Total Early-Onset Cataract

Cataract 44 And Hypotrichosis

Cataract And Hypotrichosis

Cataract, Type 44
Bardet-Biedl Syndrome 1

BBS1

Bardet-Biedl Syndrome 1, Modifier Of

Bardet-Biedl Syndrome

BBS

Bardet-Biedl Syndrome, Type 1

Laurence-Moon-Bardet-Biedl Syndrome
Iminoglycinuria

Iminoglycinuria, Digenic

IG
Leber Plus Disease

Leber Congenital Amaurosis

Lca

Leber'S Amaurosis

Leber'S Disease

Amaurosis Congenita Of Leber

Amaurosis Congenita Of Leber, Type 1

Lhon Plus Disease

Congenital Absence Of The Rods And Cones

Congenital Retinal Blindness

Crb

Congenital Amaurosis Of Retinal Origin

Leber'S Congenital Amaurosis

Leber Congenital Amaurosis 1

Leber'S Congenital Tapetoretinal Degeneration

Leber'S Congenital Tapetoretinal Dysplasia

Lca1

Leber Congenital Amaurosis Type 1

Retinal Blindness, Congenital

Amaurosis, Leber Congenital

Dysgenesis Neuroepithelialis Retinae

Hereditary Epithelial Dysplasia Of Retina

Hereditary Retinal Aplasia

Heredoretinopathia Congenitalis

Leber Abiotrophy

Leber Congenital Tapetoretinal Degeneration

Lebers Congenital Amaurosis

Optic Atrophy, Hereditary, Leber
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15867 XCL2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus XCL2 MGD MGI:104593
Rattus norvegicus XCL2 NCBI
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