UBE2B - ubiquitin conjugating enzyme E2 B Gene

中文名称：泛素结合酶 E2 B

种属: Homo sapiens

同用名: HR6B; UBC2; HHR6B; RAD6B; E2-17kDa

关于 UBE2B

功能概要

用泛素修饰蛋白质是靶向异常或短寿命蛋白质进行降解的重要细胞机制。泛素化至少涉及三类酶：泛素激活酶或 E1、泛素结合酶或 E2，以及泛素-蛋白质连接酶或 E3。该基因编码 E2 泛素结合酶家族的成员。这种酶是复制后 DNA 损伤修复所必需的。其蛋白质序列与小鼠、大鼠和兔的同系物 100% 相同，表明该酶在真核生物进化中高度保守。[RefSeq 提供，2008 年 7 月]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. This Enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this Enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]