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  2. RAB11FIP1 - RAB11 family interacting protein 1 Gene

RAB11FIP1 - RAB11 family interacting protein 1 Gene

中文名称:RAB11 家族相互作用蛋白 1

种属: Homo sapiens

同用名: RCP; NOEL1A; rab11-FIP1

基因 ID: 80223 | 基因类型: protein coding

关于 RAB11FIP1

Cytogenetic location: 8p11.23 Genomic coordinates (GRCh38): 8:37,858,618-37,899,497 (from NCBI)

This gene has 6 transcripts (splice variants), 164 orthologues and 2 paralogues. Broad expression in lung (RPKM 41.1), small intestine (RPKM 24.3) and 22 other tissues.

功能概要

该基因编码一种 Rab11 家族相互作用蛋白 (Rab11-FIPs) ,它在 Rab-11 介导的囊泡循环中发挥作用。编码的蛋白质可能参与胞吞分选、包括整合素亚基和表皮生长因子受体 (EGFR) 在内的蛋白质运输,以及循环核内体和跨高尔基体网络之间的运输。可变剪接导致多个转录本变体。 X 染色体上描述了一个假基因。[RefSeq 提供,2013 年 12 月]

This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including Integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome. [provided by RefSeq, Dec 2013]

RAB11FIP1 基因产物(2)

mRNA Protein Name
NM_001002814.3 NP_001002814.2 rab11 family-interacting protein 1 isoform 3
NM_025151.5 NP_079427.4 rab11 family-interacting protein 1 isoform 1

RAB11FIP1 蛋白结构

C2

C2: C2 domain (21 - 107)

RBD-FIP

RBD-FIP: FIP domain (1226 - 1273)

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  • 1283 a.a.
蛋白主名 其他名称

rab11 family-interacting protein 1

RAB11 coupling protein

直系同源

种属 基因名 来源 基因 ID
Bos taurus RAB11FIP1 VGNC VGNC:33616
Felis catus RAB11FIP1 VGNC VGNC:64467
Macaca mulatta RAB11FIP1 VGNC VGNC:104491
Mus musculus RAB11FIP1 MGD MGI:1923017
Rattus norvegicus RAB11FIP1 RGD RGD:1562965