2. Gene
  3. ZBP1 - Z-DNA binding protein 1 Gene

ZBP1 - Z-DNA binding protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Z-DNA 结合蛋白 1

种属: Homo sapiens

同用名: DAI; DLM1; DLM-1; C20orf183

基因 ID: 81030 | 基因类型: protein coding

关于 ZBP1

Cytogenetic location: 20q13.31 Genomic coordinates (GRCh38): 20:57,603,852-57,620,426 (from NCBI)

This gene has 9 transcripts (splice variants) and 83 orthologues. Biased expression in spleen (RPKM 3.6), appendix (RPKM 3.2) and 13 other tissues.

功能概要

该基因编码 Z-DNA 结合蛋白。编码的蛋白质通过与外来 DNA 结合并诱导 I 型干扰素产生，在先天免疫反应中发挥作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 12 月]

This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

ZBP1 基因产物(5)

mRNA Protein Name
NM_001160417.2 NP_001153889.1 Z-DNA-binding protein 1 isoform b
NM_001160418.2 NP_001153890.1 Z-DNA-binding protein 1 isoform c
NM_001160419.3 NP_001153891.1 Z-DNA-binding protein 1 isoform d
NM_001323966.2 NP_001310895.1 Z-DNA-binding protein 1 isoform e
NM_030776.3 NP_110403.2 Z-DNA-binding protein 1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
17618271 GOA
enables RNA binding IDA
IDA: 通过直接分析推断
34192517 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
19095800 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19590578 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antiviral innate immune response IDA
IDA: 通过直接分析推断
34192517 GOA
involved in defense response to virus IMP
IMP: 通过突变表型推断
32200799 GOA
involved in positive regulation of necroptotic process IMP
IMP: 通过突变表型推断
32200799 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
16876127 GOA
located in cytosol IDA
IDA: 通过直接分析推断
17618271 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16876127 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZBP1 蛋白结构

z-alpha

z-alpha: Adenosine deaminase z-alpha domain (14 - 66)

z-alpha

z-alpha: Adenosine deaminase z-alpha domain (107 - 150)

RHIM

RHIM: RIP homotypic interaction motif (177 - 215)

RHIM

RHIM: RIP homotypic interaction motif (262 - 274)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 429 a.a.
蛋白主名 其他名称

Z-DNA-binding protein 1

DNA-dependent activator of IRFs

ZBP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZBP1 Q9H171 RIPK3 Homo sapiens Q9Y572
Anti Tag CoIP
19590578
种属内
ZBP1 Q9H171 KRR1 Homo sapiens Q13601
Anti Tag CoIP
19590578
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ZBP1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71436 ZBP1 Protein, Human (His) Q9H171-1 (M1-S149) ≥95%

关联疾病

疾病名称 别名
Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified
Zika Virus Congenital Syndrome

Zikv Congenital Infection
Variola Minor

Alastrim

Cottonpox

Milkpox

Whitepox
Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-144873 AVJ16 Inducer 99.60% 否
HY-162424 ZBP1/RIP3/MLKL activator 1 Activator 99.73% 否
HY-RS15958 ZBP1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS06619 IGF2BP1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16687 Zbp1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16849 Igf2bp1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23122 Zbp1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23290 Igf2bp1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ZBP1 RGD RGD:619956
Macaca mulatta ZBP1 VGNC VGNC:79013
Mus musculus ZBP1 MGD MGI:1927449
Canis familiaris ZBP1 VGNC VGNC:54745
Felis catus ZBP1 VGNC VGNC:81262
Bos taurus ZBP1 VGNC VGNC:37056
Others ZBP1 NCBI
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