2. Gene
  3. Rock1 - Rho-associated coiled-coil containing protein kinase 1 Gene

Rock1 - Rho-associated coiled-coil containing protein kinase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：含 Rho 相关卷曲螺旋蛋白激酶 1

种属: Rattus norvegicus

同用名: ROCK-I; P160Rock

基因 ID: 81762 | 基因类型: protein coding

关于 Rock1

Primary_assembly 18: 1,115,905-1,235,571 reverse strand.mRatBN7.2:CM026991.1

This gene has 2 transcripts (splice variants), 212 orthologues, 5 paralogues and is associated with 7 phenotypes. Biased expression in Thymus (RPKM 255.8), Lung (RPKM 241.4) and 9 other tissues.

功能概要

该基因编码的蛋白可启动小 GTPase 绑定活动。参与细胞骨架组织；基因表达的正调控；和对转化生长因子 β 的反应。作用于 Rho 蛋白信号转导的上游或内部。预计位于lamellipodium；质膜;和荷叶边。预计是淀粉样蛋白-β 复合物的一部分。预计在细胞质应激颗粒和细胞骨架中具有活性。与人 ROCK1 同源（Rho 相关的卷曲螺旋含有蛋白激酶 1）。 [由基因组资源联盟提供，2022 年 4 月]

Enables small GTPase binding activity. Involved in Cytoskeleton organization; positive regulation of gene expression; and response to transforming growth factor beta. Acts upstream of or within Rho protein signal transduction. Predicted to be located in lamellipodium; plasma membrane; and ruffle. Predicted to be part of amyloid-beta complex. Predicted to be active in cytoplasmic stress granule and Cytoskeleton. Orthologous to human ROCK1 (Rho associated coiled-coil containing protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Rock1 基因产物(1)

mRNA Protein Name
NM_001389239.1 NP_001376168.1 rho-associated protein kinase 1

Rock1 蛋白结构

STKc_ROCK1

STKc_ROCK1: cd05622 (1 - 405)

SMC_prok_B

SMC_prok_B: cl37069 (425 - 1096)

HR1_ROCK1

HR1_ROCK1: cd11639 (488 - 553)

ROCK_SBD

ROCK_SBD: cd22250 (835 - 912)

PH_ROCK

PH_ROCK: cd01242 (1118 - 1224)

C1_ROCK1

C1_ROCK1: cd20874 (1221 - 1289)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1354 a.a.
蛋白主名 其他名称

rho-associated protein kinase 1

Rho-associated coiled-coil forming kinase 1

Rho-associated kinase beta

liver regeneration-related protein LRRG199

p150 RhoA-binding kinase ROK beta

p160 ROCK-1

rho-associated, coiled-coil-containing protein kinase 1

rho-associated, coiled-coil-containing protein kinase I

相关产品

Approval
生物活性分子 (10)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10341 Fasudil Hydrochloride Inhibitor 99.96% 是
HY-15307 Belumosudil Inhibitor 99.77% 是
HY-15685 Ripasudil Inhibitor 99.92% 否
HY-13911 Hydroxyfasudil Inhibitor 98.42% 否
HY-13911A Hydroxyfasudil hydrochloride Inhibitor 98.88% 否
HY-15307A Belumosudil mesylate Inhibitor 99.88% 是
HY-10341A Fasudil Inhibitor / 否
HY-10341C Fasudil dihydrochloride Inhibitor / 否
HY-10341B Fasudil hydrochloride semihydrate Inhibitor / 否
HY-15685A Ripasudil free base Inhibitor / 否
Clinical Phase
生物活性分子 (5)
目录号 产品名 作用方式
纯度 Phase
HY-109191 Sovesudil Inhibitor 98.31% Phase 3
HY-109191A Sovesudil hydrochloride Inhibitor 99.79% Phase 3
HY-15687A SAR407899 Inhibitor 99.86% Phase 2
HY-15687 SAR407899 hydrochloride Inhibitor 98.66% Phase 2
HY-16071 AT13148 Inhibitor 99.21% Phase 1
Pre-clinical Phase
生物活性分子 (26)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10071 Y-27632 Inhibitor 99.97% 否
HY-10583 Y-27632 dihydrochloride Inhibitor 99.98% 否
HY-15392 Chroman 1 Inhibitor 99.48% 否
HY-15556 GSK269962A Inhibitor 99.83% 否
HY-11000 GSK429286A Inhibitor 98.15% 否
HY-119937 ROCK inhibitor-2 Inhibitor 99.87% 否
HY-15755 RKI-1447 Inhibitor 98.29% 否
HY-18990 GSK180736A Inhibitor 98.01% 否
HY-13300 SR-3677 Inhibitor 99.90% 否
HY-12437 BDP5290 Inhibitor 98.80% 否
HY-16758 Verosudil Inhibitor 99.18% 否
HY-14362 GSK-25 Inhibitor 99.68% 否
HY-108518 SB-772077B dihydrochloride Inhibitor ≥99.0% 否
HY-100270 Rho-Kinase-IN-1 Inhibitor 99.91% 否
HY-10319 BAY-549 Inhibitor 99.46% 否
HY-126275 HSD1590 Inhibitor 99.54% 否
HY-110339 RKI-1447 dihydrochloride Inhibitor 98.04% 否
HY-15392A Chroman 1 dihydrochloride Inhibitor 99.11% 否
HY-107209 RKI-1313 Inhibitor ≥98.0% 否
HY-132302A Hu7691 free base Inhibitor / 否
HY-132302 Hu7691 Inhibitor / 否
HY-122011 PF-4950834 Inhibitor / 否
HY-13300A SR-3677 dihydrochloride Inhibitor / 否
HY-15556A GSK269962A hydrochloride Inhibitor / 否
HY-14227 LIMK-IN-1 Inhibitor / 否
HY-149266 THK01 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rock1 NCBI NCBI:6093
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