2. Cell Cycle/DNA Damage Stem Cell/Wnt Cytoskeleton TGF-beta/Smad
  3. ROCK
  4. GSK269962A hydrochloride

GSK269962A hydrochloride  (Synonyms: GSK 269962 hydrochloride)

目录号: HY-15556A 纯度: 99.73%
COA 产品使用指南 技术支持

GSK269962A hydrochloride (GSK 269962 hydrochloride) 是一种有效的 ROCK 抑制剂，作用于重组人 ROCK1 和 ROCK2，IC50 分别为 1.6 和 4 nM。GSK269962A hydrochloride 具有抗炎和血管舒张作用。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

GSK269962A hydrochloride Chemical Structure

GSK269962A hydrochloride Chemical Structure

CAS No. : 2095432-71-4

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
5 mg ￥600
In-stock
10 mg ￥1100
In-stock
25 mg ￥1866
In-stock
50 mg ￥2800
In-stock
100 mg ￥4200
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of GSK269962A hydrochloride:

GSK269962A hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 ROCK 亚型特异性产品:

查看所有亚型
ROCK ROCK1 ROCK2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GSK269962A hydrochloride (GSK 269962 hydrochloride) is a potent ROCK inhibitor with IC50s of 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively. GSK269962A hydrochloride has anti-inflammatory and vasodilatory activities[1].

IC50 & Target[1]

ROCK1

1.6 nM (IC50)

ROCK2

4 nM (IC50)

RSK1

132 nM (IC50)

MSK1

49 nM (IC50)

AKT1

955 nM (IC50)

AKT2

1350 nM (IC50)

AKT3

1510 nM (IC50)

CDK2

3500 nM (IC50)

GSK3α

1260 nM (IC50)

体外研究
(In Vitro)

GSK269962A has an IC50 of 1.6 nM toward recombinant human ROCK1. GSK269962A exhibits more than 30-fold selectivity against a panel of serine/threonine kinases[1].
GSK269962A induces vasorelaxation in preconstricted rat aorta with an IC50 of 35 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GSK269962A hydrochloride 相关抗体:
体内研究
(In Vivo)

GSK269962A is a potent antihypertensive agent. GSK269962A (0.3, 1, and 3 mg/kg; oral gavage) induces a dose-dependent reduction in blood pressure in spontaneously hypertensive rat (SHR). The reduction of blood pressure is acute and substantial[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (350-400g)[1]
Dosage: 0.3, 1, and 3 mg/kg
Administration: Oral gavage; 12 hours
Result: Induced a dose-dependent reduction in blood pressure.
分子量

607.06

Formula

C29H31ClN8O5
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (164.73 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6473 mL 8.2364 mL 16.4728 mL
5 mM 0.3295 mL 1.6473 mL 3.2946 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

GSK269962A hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6473 mL 8.2364 mL 16.4728 mL 41.1821 mL
5 mM 0.3295 mL 1.6473 mL 3.2946 mL 8.2364 mL
10 mM 0.1647 mL 0.8236 mL 1.6473 mL 4.1182 mL
15 mM 0.1098 mL 0.5491 mL 1.0982 mL 2.7455 mL
20 mM 0.0824 mL 0.4118 mL 0.8236 mL 2.0591 mL
25 mM 0.0659 mL 0.3295 mL 0.6589 mL 1.6473 mL
30 mM 0.0549 mL 0.2745 mL 0.5491 mL 1.3727 mL
40 mM 0.0412 mL 0.2059 mL 0.4118 mL 1.0296 mL
50 mM 0.0329 mL 0.1647 mL 0.3295 mL 0.8236 mL
60 mM 0.0275 mL 0.1373 mL 0.2745 mL 0.6864 mL
80 mM 0.0206 mL 0.1030 mL 0.2059 mL 0.5148 mL
100 mM 0.0165 mL 0.0824 mL 0.1647 mL 0.4118 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK269962A2095432-71-4GSK 269962GSK269962GSK-269962ROCKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKROCK1ROCK2anti-inflammatoryvasodilatorycardiovascularantihypertensivebloodpressureInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
GSK269962A hydrochloride
目录号：
HY-15556A
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z