PARP9 - poly(ADP-ribose) polymerase family member 9 Gene

中文名称：聚 (ADP-核糖) 聚合酶家族成员 9

种属: Homo sapiens

同用名: BAL; BAL1; ARTD9; MGC:7868

基因 ID: 83666 | 基因类型: protein coding

关于 PARP9

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:122,527,924-122,564,784 (from NCBI)

This gene has 8 transcripts (splice variants), 250 orthologues and 8 paralogues. Ubiquitous expression in spleen (RPKM 10.3), appendix (RPKM 10.1) and 25 other tissues.

功能概要

启用多种功能，包括 ADP-D-核糖结合活性； NAD+ ADP-核糖基转移酶活性；和 STAT 家族蛋白结合活性。参与多个过程，包括正向调节氮化合物代谢过程；防御反应的调节；和基因表达的调控。位于几种细胞成分中，包括线粒体；核质；和 DNA 损伤部位。部分含蛋白质复合物。与细胞核共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including ADP-D-ribose binding activity; NAD+ ADP-ribosyltransferase activity; and STAT family protein binding activity. Involved in several processes, including positive regulation of nitrogen compound metabolic process; regulation of defense response; and regulation of gene expression. Located in several cellular components, including mitochondrion; nucleoplasm; and site of DNA damage. Part of protein-containing complex. Colocalizes with nucleus. [provided by Alliance of Genome Resources, Apr 2022]

PARP9 基因产物(23)

mRNA	Protein	Name
NM_001146102.2	NP_001139574.1	protein mono-ADP-ribosyltransferase PARP9 isoform a
NM_001146103.2	NP_001139575.1	protein mono-ADP-ribosyltransferase PARP9 isoform b
NM_001146104.2	NP_001139576.1	protein mono-ADP-ribosyltransferase PARP9 isoform b
NM_001146105.2	NP_001139577.1	protein mono-ADP-ribosyltransferase PARP9 isoform b
NM_001146106.3	NP_001139578.1	protein mono-ADP-ribosyltransferase PARP9 isoform c
NM_001387871.1	NP_001374800.1	protein mono-ADP-ribosyltransferase PARP9 isoform a
NM_001387872.1	NP_001374801.1	protein mono-ADP-ribosyltransferase PARP9 isoform a
NM_001387873.1	NP_001374802.1	protein mono-ADP-ribosyltransferase PARP9 isoform d
NM_001387874.1	NP_001374803.1	protein mono-ADP-ribosyltransferase PARP9 isoform d
NM_001387875.1	NP_001374804.1	protein mono-ADP-ribosyltransferase PARP9 isoform b
NM_001387876.1	NP_001374805.1	protein mono-ADP-ribosyltransferase PARP9 isoform b
NM_001387877.1	NP_001374806.1	protein mono-ADP-ribosyltransferase PARP9 isoform b
NM_001387878.1	NP_001374807.1	protein mono-ADP-ribosyltransferase PARP9 isoform e
NM_001387879.1	NP_001374808.1	protein mono-ADP-ribosyltransferase PARP9 isoform e
NM_001387880.1	NP_001374809.1	protein mono-ADP-ribosyltransferase PARP9 isoform f
NM_001387881.1	NP_001374810.1	protein mono-ADP-ribosyltransferase PARP9 isoform g
NM_001387882.1	NP_001374811.1	protein mono-ADP-ribosyltransferase PARP9 isoform g
NM_001387883.1	NP_001374812.1	protein mono-ADP-ribosyltransferase PARP9 isoform g
NM_001387884.1	NP_001374813.1	protein mono-ADP-ribosyltransferase PARP9 isoform g
NM_001387885.1	NP_001374814.1	protein mono-ADP-ribosyltransferase PARP9 isoform c
NM_001387886.1	NP_001374815.1	protein mono-ADP-ribosyltransferase PARP9 isoform c
NM_001387887.1	NP_001374816.1	protein mono-ADP-ribosyltransferase PARP9 isoform c
NM_031458.3	NP_113646.2	protein mono-ADP-ribosyltransferase PARP9 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ADP-D-ribose binding	IMP IMP: 通过突变表型推断	26479788	GOA
NOT enables NAD+ binding	IMP IMP: 通过突变表型推断	16061477	GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA IDA: 通过直接分析推断	23230272	GOA
NOT enables NAD+-protein poly-ADP-ribosyltransferase activity	IMP IMP: 通过突变表型推断	16061477	GOA
enables NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity	IDA IDA: 通过直接分析推断	28525742	GOA
enables STAT family protein binding	IPI IPI: 通过物理相互作用推断	26479788	GOA
enables enzyme binding	IPI IPI: 通过物理相互作用推断	27796300	GOA
enables enzyme inhibitor activity	IDA IDA: 通过直接分析推断	27796300	GOA
enables histone binding	IPI IPI: 通过物理相互作用推断	26479788	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16809771	GOA
enables transcription corepressor activity	IMP IMP: 通过突变表型推断	16061477	GOA
enables ubiquitin-like protein ligase binding	IPI IPI: 通过物理相互作用推断	28525742	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage checkpoint signaling	IMP IMP: 通过突变表型推断	28525742	GOA
involved in double-strand break repair	IMP IMP: 通过突变表型推断	23230272	GOA
involved in negative regulation of catalytic activity	IDA IDA: 通过直接分析推断	27796300	GOA
involved in negative regulation of gene expression	IMP IMP: 通过突变表型推断	27796300	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	16061477	GOA
involved in positive regulation of DNA-templated transcription	IGI IGI: 通过遗传相互作用推断	26479788	GOA
involved in positive regulation of chromatin binding	IGI IGI: 通过遗传相互作用推断	26479788	GOA
involved in positive regulation of defense response to virus by host	IGI IGI: 通过遗传相互作用推断	26479788	GOA
involved in positive regulation of protein localization to nucleus	IGI IGI: 通过遗传相互作用推断	26479788	GOA
involved in positive regulation of type II interferon-mediated signaling pathway	IMP IMP: 通过突变表型推断	27796300	GOA
involved in positive regulation of tyrosine phosphorylation of STAT protein	IMP IMP: 通过突变表型推断	27796300	GOA
involved in post-transcriptional regulation of gene expression	IMP IMP: 通过突变表型推断	26479788	GOA
NOT involved in protein poly-ADP-ribosylation	IMP IMP: 通过突变表型推断	16061477	GOA
involved in regulation of response to type II interferon	IDA IDA: 通过直接分析推断	16809771	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	16809771	GOA
colocalizes with nucleus	IDA IDA: 通过直接分析推断	26479788	GOA
located in nucleus	IDA IDA: 通过直接分析推断	16809771	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	26479788	GOA
located in site of DNA damage	IDA IDA: 通过直接分析推断	28525742	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PARP9 蛋白结构

Macro

0
200
400
600
800
854 a.a.

蛋白主名

其他名称

protein mono-ADP-ribosyltransferase PARP9

ADP-ribosyltransferase diphtheria toxin-like 9

关联疾病

疾病名称

别名

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

B-Cell Lymphoma

Lymphoma, B-Cell	B-Cell Lymphomas
B-Cell Lymphocytic Neoplasm	Lymphoma B-Cell
B-Cell Lymphoma Nos

Osebold-Remondini Syndrome

Brachydactyly Type A6	Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities
Bda6	Brachydactyly, Type A6

Arthrogryposis, Renal Dysfunction, And Cholestasis 1

Arc Syndrome	ARCS1
Arthrogryposis Renal Dysfunction Cholestasis Syndrome	Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome
Arcs	Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome
Arthrogryposis, Renal Dysfunction, And Cholestasis	Arthrogryposis-Renal Dysfunction-Cholestasis
Arthrogryposis - Renal Dysfunction - Cholestasis	Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis
Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1	Arthrogryposis Renal Dysfunction And Cholestasis 1
Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome	Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1
Kidney Failure	Renal Insufficiency

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-170942	CDK9/PARP-IN-1	Inhibitor	/	否
HY-RS10071	PARP9 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS20074	Parp9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS26577	Parp9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PARP9	RGD	RGD:1307534
Mus musculus	PARP9	MGD	MGI:1933117
Macaca mulatta	PARP9	VGNC	VGNC:84057
Bos taurus	PARP9	VGNC	VGNC:53596
Felis catus	PARP9	VGNC	VGNC:102799
Canis familiaris	PARP9	VGNC	VGNC:53084

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PARP9 - poly(ADP-ribose) polymerase family member 9 Gene

关于 PARP9

功能概要

PARP9 基因产物(23)

PARP9 蛋白结构

关联疾病

直系同源

热门区域

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PARP9 - poly(ADP-ribose) polymerase family member 9 Gene

关于 PARP9

功能概要

PARP9 基因产物(23)

PARP9 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z