2. Gene
  3. Usp8 - ubiquitin specific peptidase 8 Gene

Usp8 - ubiquitin specific peptidase 8 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ubpy; mKIAA0055

基因 ID: 84092 | 基因类型: protein coding

关于 Usp8

功能概要

Enables thiol-dependent Deubiquitinase. Involved in endosome organization and protein deubiquitination. Acts upstream of or within Ras protein signal transduction. Located in acrosomal membrane; cytosol; and midbody. Is extrinsic component of endosome membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Orthologous to human USP8 (ubiquitin specific peptidase 8). [provided by Alliance of Genome Resources, Apr 2022]

Usp8 基因产物(2)

mRNA Protein Name
NM_001252580.1 NP_001239509.1 ubiquitin carboxyl-terminal hydrolase 8 isoform 1
NM_019729.3 NP_062703.2 ubiquitin carboxyl-terminal hydrolase 8 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type deubiquitinase activity IDA
IDA: 通过直接分析推断
11500497 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10982817 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Ras protein signal transduction IPI
IPI: 通过物理相互作用推断
11500497 MGI
involved in endosome organization IMP
IMP: 通过突变表型推断
16771824 MGI
acts upstream of or within protein deubiquitination IDA
IDA: 通过直接分析推断
15342353 MGI
involved in protein deubiquitination IDA
IDA: 通过直接分析推断
16120644 MGI
involved in protein deubiquitination IMP
IMP: 通过突变表型推断
15314180 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in acrosomal membrane IDA
IDA: 通过直接分析推断
15342353 MGI
located in cytosol IDA
IDA: 通过直接分析推断
16120644 MGI
located in endosome membrane IDA
IDA: 通过直接分析推断
16120644 MGI
located in intracellular anatomical structure IDA
IDA: 通过直接分析推断
11500497 MGI
located in midbody IDA
IDA: 通过直接分析推断
18388320 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ubiquitin carboxyl-terminal hydrolase 8

deubiquitinating enzyme 8

putative deubiquitinating enzyme

ubiquitin isopeptidase Y

ubiquitin thioesterase 8

ubiquitin thiolesterase 8

ubiquitin-specific-processing protease 8

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-151563A OTUB1/USP8-IN-1 TFA Inhibitor 99.56% 否
HY-162312 LLK203 Inhibitor 98.58% 否
HY-149902 USP8-IN-3 Inhibitor 99.17% 否
HY-149901 USP8-IN-2 Inhibitor 99.91% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Usp8 NCBI NCBI:9101
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