Hrh3 - histamine receptor H3 Gene

中文名称：组胺受体H3

种属: Rattus norvegicus

关于 Hrh3

功能概要

该基因编码属于 G 蛋白偶联受体超家族的组胺 H3 受体。这种蛋白质作为大脑中组胺神经元的突触前自身受体，以及中枢和周围神经系统中不含组胺的神经元的突触前异受体。它被认为是开发治疗多种疾病的重要目标，包括肥胖症、癫痫症以及注意力缺陷多动障碍和阿尔茨海默病等认知疾病。已经针对该基因描述了几种编码不同亚型、具有不同大脑表达模式和信号传导特性的可变剪接转录物变体。 [RefSeq 提供，2012 年 7 月]

This gene encodes a histamine H3 receptor that belongs to the superfamily of G-protein coupled receptors. This protein functions as a presynaptic autoreceptor on histamine neurons in the brain, and a presynaptic heteroreceptor in nonhistamine-containing neurons in both the central and peripheral nervous systems. It is deemed a great target for the development of therapeutics for numerous disorders, including obesity, epilepsy, and such cognitive diseases as attention deficit hyperactivity disorder and Alzheimer's disease. Several alternatively spliced transcript variants encoding different isoforms, with different brain expression patterns and signaling properties, have been described for this gene. [provided by RefSeq, Jul 2012]