SCRT2 - scratch family transcriptional repressor 2 Gene

中文名称：scratch 家族转录抑制因子 2

种属: Homo sapiens

同用名: ZNF898B

基因 ID: 85508 | 基因类型: protein coding

关于 SCRT2

This gene has 1 transcript (splice variant), 104 orthologues and 36 paralogues. Low expression observed in reference dataset.

功能概要

启用序列特异性双链 DNA 结合活性。预计通过死亡域受体参与外源性凋亡信号通路的负调节和 RNA 聚合酶 II 的转录负调节。预计在神经元迁移调节的上游或调节范围内起作用。预测位于染色质中。 [由基因组资源联盟提供，2022 年 4 月]

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of neuron migration. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Apr 2022]

SCRT2 基因产物(1)

mRNA	Protein	Name
NM_033129.4	NP_149120.1	transcriptional repressor scratch 2

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SCRT2 蛋白结构

zf-C2H2

zf-H2C2_2

0
100
200
307 a.a.

蛋白主名

其他名称

transcriptional repressor scratch 2

scratch 2 protein

关联疾病

疾病名称

别名

Retinitis Pigmentosa 58

RP58	Retinitis Pigmentosa, Type 58

Metaphyseal Chondrodysplasia, Schmid Type

MCDS	Schmid Metaphyseal Chondrodysplasia
Metaphyseal Chondrodysplasia Schmid Type	Spondylometaphyseal Dysplasia, Japanese Type
Japanese Type Spondylometaphyseal Dysplasia	Schmid Type Metaphyseal Dysplasia
Metaphyseal Chondrodysplasia Type Schmid	Schmid Type Metaphyseal Chondrodysplasia
SMCD	Chondrodysplasia, Metaphyseal, Schmid Type
Corneal Dystrophy, Subepithelial Mucinous

Limited Scleroderma

Limited Cutaneous Systemic Sclerosis	Limited Systemic Sclerosis
Systemic Sclerosis Sine Scleroderma	Crest Syndrome
Limited Cutaneous Systemic Scleroderma	Scleroderma, Limited
Systemic Sclerosis, Limited	Progressive Systemic Sclerosis Sine Scleroderma
Scleroderma, Sine	Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome
Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12566	SCRT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	SCRT2	VGNC	VGNC:64936
Mus musculus	SCRT2	MGD	MGI:2139287
Rattus norvegicus	SCRT2	RGD	RGD:1564796
Bos taurus	SCRT2	VGNC	VGNC:106918
Macaca mulatta	SCRT2	VGNC	VGNC:108033

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