CCNT2 - cyclin T2 Gene

中文名称：细胞周期素 T2

种属: Homo sapiens

同用名: CYCT2

基因 ID: 905 | 基因类型: protein coding

关于 CCNT2

Cytogenetic location: 2q21.3 Genomic coordinates (GRCh38): 2:134,918,822-134,959,342 (from NCBI)

This gene has 10 transcripts (splice variants), 293 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 8.2), testis (RPKM 7.2) and 25 other tissues.

功能概要

由该基因编码的蛋白质属于高度保守的细胞周期蛋白家族，其成员的特点是在整个细胞周期中蛋白质丰度具有显着的周期性。细胞周期蛋白作为 CDK 激酶的调节剂发挥作用。不同的细胞周期蛋白表现出不同的表达和降解模式，这有助于每个有丝分裂事件的时间协调。该细胞周期蛋白及其激酶伴侣 CDK9 被发现是转录延伸因子 p-TEFb 的亚基。据报道，含有这种细胞周期蛋白的 p-TEFb 复合物与人类免疫缺陷病毒 1 型 (HIV-1) Tat 蛋白相互作用，并作为其负调节因子起作用。在 1 号染色体上发现了该基因的假基因。交替剪接导致多个转录变体。[RefSeq 提供，2010 年 12 月]

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

CCNT2 基因产物(4)

mRNA	Protein	Name
NM_001241.4	NP_001232.1	cyclin-T2 isoform a
NM_001320748.2	NP_001307677.1	cyclin-T2 isoform d
NM_001320749.2	NP_001307678.1	cyclin-T2 isoform e
NM_058241.3	NP_490595.1	cyclin-T2 isoform b

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 7SK snRNA binding	IDA IDA: 通过直接分析推断	11713533	GOA
enables RNA polymerase binding	IPI IPI: 通过物理相互作用推断	15563843	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9499409	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	16331689	GOA
enables transcription coactivator binding	IPI IPI: 通过物理相互作用推断	12037672	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in early viral transcription	IDA IDA: 通过直接分析推断	21509660	GOA
involved in late viral transcription	IDA IDA: 通过直接分析推断	21509660	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	15563843	GOA
involved in positive regulation of transcription elongation by RNA polymerase II	IDA IDA: 通过直接分析推断	9499409	GOA
involved in regulation of muscle cell differentiation	IDA IDA: 通过直接分析推断	16331689	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of cyclin/CDK positive transcription elongation factor complex	IDA IDA: 通过直接分析推断	9499409	GOA
part of cyclin/CDK positive transcription elongation factor complex	IPI IPI: 通过物理相互作用推断	9499409	GOA
located in nucleus	IDA IDA: 通过直接分析推断	9499409	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCNT2 蛋白结构

Cyclin_N

0
200
400
600
730 a.a.

蛋白主名

其他名称

cyclin-T2

SDS-stable vimentin-bound DNA fragment HEF42VIM22

关联疾病

疾病名称

别名

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02142	CCNT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS21507	Ccnt2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS28025	Ccnt2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	CCNT2	VGNC	VGNC:38907
Rattus norvegicus	CCNT2	RGD	RGD:1309205
Felis catus	CCNT2	VGNC	VGNC:60568
Macaca mulatta	CCNT2	VGNC	VGNC:70736
Bos taurus	CCNT2	VGNC	VGNC:26979
Mus musculus	CCNT2	MGD	MGI:1920199
Others	CCNT2	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CCNT2 - cyclin T2 Gene

关于 CCNT2

功能概要

CCNT2 基因产物(4)

CCNT2 蛋白结构

关联疾病

直系同源

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CCNT2 - cyclin T2 Gene

关于 CCNT2

功能概要

CCNT2 基因产物(4)

CCNT2 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z