1. Gene
  2. GSTO1 - glutathione S-transferase omega 1 Gene

GSTO1 - glutathione S-transferase omega 1 Gene

中文名称:谷胱甘肽 S-转移酶 omega 1

种属: Homo sapiens

同用名: P28; SPG-R; GSTO 1-1; GSTTLp28; HEL-S-21

基因 ID: 9446 | 基因类型: protein coding

关于 GSTO1

Cytogenetic location: 10q25.1 Genomic coordinates (GRCh38): 10:104,254,173-104,267,455 (from NCBI)

This gene has 7 transcripts (splice variants), 254 orthologues and 14 paralogues. Ubiquitous expression in liver (RPKM 91.8), heart (RPKM 47.6) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种欧米茄类谷胱甘肽 S-转移酶 (GST) ,具有谷胱甘肽依赖性硫醇转移酶和脱氢抗坏血酸还原酶活性。 GST 参与外源物质和致癌物质的代谢。编码的蛋白质作为同源二聚体存在于细胞质中。已发现该基因的三个转录变体编码不同的亚型。[RefSeq 提供,2010 年 7 月]

The protein encoded by this gene is an omega class Glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GSTO1 基因产物(3)

mRNA Protein Name
NM_001191002.2 NP_001177931.1 glutathione S-transferase omega-1 isoform 2
NM_001191003.2 NP_001177932.1 glutathione S-transferase omega-1 isoform 3
NM_004832.3 NP_004823.1 glutathione S-transferase omega-1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glutathione dehydrogenase (ascorbate) activity IDA
IDA: 通过直接分析推断
11511179 GOA
enables glutathione transferase activity IDA
IDA: 通过直接分析推断
11511179 GOA
enables oxidoreductase activity IDA
IDA: 通过直接分析推断
11511179 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25277244 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11511179 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GSTO1 蛋白结构

GST_N_3

GST_N_3: Glutathione S-transferase, N-terminal domain (27 - 100)

GST_C

GST_C: Glutathione S-transferase, C-terminal domain (131 - 209)

  • 0
  • 100
  • 200
  • 241 a.a.
蛋白主名 其他名称

glutathione S-transferase omega-1

MMA(V) reductase

GSTO1 抗体

目录号 产品名 应用 反应物种
HY-P82350 GSTO1 Antibody (YA2095) WB, IHC-P, ICC/IF Human, Rat

关联疾病

疾病名称 别名
Night Blindness, Congenital Stationary, Type 1a

Congenital Stationary Night Blindness 1a

CSNB1A

Hemeralopia-Myopia

Myopia-Night Blindness

Night Blindness, Congenital Stationary , 1a, X-Linked

Congenital Stationary Night Blindness With Myopia

Csnb, Complete, X-Linked

Night Blindness, Congenital Stationary, With Myopia

Nbm1

Complete Csnb X-Linked

Congenital Stationary Night Blindness 1a X-Linked

Nbmi

Night Blindness, Congenital Stationary, 1a

Complete X-Linked Csnb

Nyctalopia

Xlcsnb

X-Linked Congenital Stationary Night Blindness

Blindness, Night, Stationary, Congenital, Type 1a

Night Blindness

X-Linked Csnb

Night Blindness, Congenital Stationary, Type 2a

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus GSTO1 VGNC VGNC:62731
Canis familiaris GSTO1 VGNC VGNC:41536
Mus musculus GSTO1 MGD MGI:1342273
Rattus norvegicus GSTO1 RGD RGD:70952